Clinical Publication
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Walk! A Long-Term Observational Investigation of Knee Osteoarthritis
The results of an observational study of more than 1,000 individuals age 50 years and older with knee arthritis revealed regular walking for exercise correlated with fewer reports of new knee pain and slower disease progression, as verified by radiographic evidence at eight-year follow-up.
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Antidepressants for Chronic Pain: Do They Work?
Antidepressant medications have been widely used for treating a variety of chronic pain disorders, but strong evidence to support their efficacy is lacking. Some patients may respond, but available data do not help us determine which agents may be helpful in a specific type of chronic pain condition.
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Alcohol: Double-Edged Sword, or Hatchet?
Researchers reported consuming two to 14 alcoholic drinks per week was associated with fewer major adverse cardiovascular events, which the authors noted could be explained in part by less stress-related neural activity demonstrated on PET and CT scans.
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Physician Group Says to Start Colon Cancer Screening at Age 50 Years
Patient advocates push back, standing by other recommendations that set the age at 45 years.
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A Closer Look at the Effects of Screen Time on Adolescent Mental Health
This systematic review of 50 studies reveals a correlation between increased social media usage and decreased mental well-being in adolescents of both genders, more significant depression in girls, and an association of high weekday smartphone usage with reduced mental well-being across both sexes. However, the inconsistency of the findings necessitates additional studies before generalization.
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A Component of Tea to Promote Sleep: A Review of L-theanine as Treatment for Insomnia
This review of eight studies encompassing 417 patients assesses the effectiveness of L-theanine on sleep disorders. Results were inconsistent, but avenues of future study were identified.
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What Kind of Bundle Branch Block?
Assuming QRS widening in a supraventricular rhythm is not the result of hyperkalemia or other toxicity, and assuming the patient has not been diagnosed with Wolff-Parkinson-White syndrome, classification of 12-lead ECG conduction disturbances can be simplified into one of three basic categories. The tracing in the figure illustrates this concept.
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Donislecel-jujn Allogenic Pancreatic Islet Cellular Suspension (Lantidra)
Lantidra can be prescribed to adults with type 1 diabetes who cannot approach target HbA1c levels because of current repeated episodes of severe hyperglycemia despite intensive diabetes management and education.
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Report from the 2023 American Diabetes Association Scientific Sessions
At the 2023 American Diabetes Association Scientific Sessions, experts presented key updates, advances, and best practices for patient care. A selection of presentations relevant to the internal medicine and primary care community is presented here.
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Reconsidering Aspirin Therapy for Elderly Patients
A post-hoc analysis of the ASPREE trial revealed that in presumably healthy elderly subjects, taking low-dose aspirin daily over three years was associated with a significant drop in hemoglobin and ferritin levels vs. placebo, even when patients with major bleeding events were excluded.