Clinical Publication
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Triglyceride-Lowering Therapy and Cardiovascular Events
Researchers studied pemafibrate vs. placebo in patients with type 2 diabetes, mild-to-moderate triglyceride elevations, and low levels of HDL and well-controlled LDL cholesterol. Despite a 31% reduction in triglyceride levels, there was no improvement in the risk of cardiovascular outcomes over a median follow-up of 3.4 years.
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COVID-19: Beware Remdesivir Resistance
Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.
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Is Screening for Atrial Fibrillation Cost Effective?
Self-screening for atrial fibrillation in elderly individuals could lead to lower stroke rates, prevent bleeding-related hospitalizations, and save money.
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Fecal Microbiota, live-jslm (Rebyota)
Rebyota can be prescribed to prevent recurring Clostridioides difficile infection for patients age 18 years and older who are following antibiotic treatment for recurring episodes.
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Is AV Block Complete?
Does the ECG in the figure represent complete AV block? If not, why not?
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How Does Public Policy Affect Diet and Health?
The World Health Organization sponsored this systemic review and meta-analysis to analyze the effect of food subsidies and taxes on population-level changes in diet and health outcomes.
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Effects of Sodium Restriction in Chronic, Stable Heart Failure Patients
A study of a low-sodium diet for chronic, stable heart failure patients after one year showed no difference in hard clinical outcomes, but the degree of sodium restriction was modest.
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Do NSAIDs Cause More Chronic Pain?
Acute inflammation may protect against the development of chronic pain through neutrophil activation. Using nonsteroidal anti-inflammatory drugs may blunt that response and contribute to chronic pain.
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Alzheimer’s Research Funding Receives Boost
The fiscal year 2023 federal budget also includes provisions to strengthen accelerated drug approval and Alzheimer’s public health infrastructure.
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Long-Term Statin Use Associated with Lower Stroke Risk
A cohort of Danish patients who were taking the cholesterol control medication were less likely to experience an intracerebral hemorrhage.