Clinical Publication
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High-Impact Clinical Trials from the European Society of Cardiology Congress 2023
The following is an overview of important cardiology research presented Aug. 25 through Aug. 28 in Amsterdam and online during the ESC Congress 2023.
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Is Planned Complete Revascularization After Myocardial Infarction Wise for Older Patients?
Among patients at least age 75 years presenting with acute myocardial infarction and multivessel coronary disease, physiology-guided complete revascularization led to a lower risk of major adverse cardiovascular events at one year vs. culprit lesion-only percutaneous coronary intervention.
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Supine Blood Pressure Readings May Reveal Hidden Health Risks
Measuring a patient’s blood pressure while he or she is lying down could help clinicians learn more about possible underlying heart problems.
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Syncope and Complete AV Block?
The rhythm strip shown in the figure was recorded from a patient with syncope. It was interpreted as consistent with complete AV block. Do you agree with that interpretation?
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Zuranolone Capsules (Zurzuvae)
Zuranolone can be prescribed to treat postpartum depression.
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The Degree of Pyuria Can Help Determine Urinary Tract Infection in Elderly Women
Elderly women with a urinary tract infection recorded a higher median number of urinary leukocytes compared to uninfected controls, including those with asymptomatic bacteriuria. For 264 leukocytes/µL, the sensitivity and specificity of microscopy were 88%. Using the standard pyuria threshold of 10 leukocytes/µL gave a specificity of 36% and a sensitivity of 100%.
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Treating Psychotic Symptoms Among Alzheimer’s Disease Patients
In a meta-analysis of several large treatment trials of patients with Alzheimer’s disease, Parkinson’s disease, and dementia with Lewy bodies, cholinesterase inhibitors demonstrated a small but statistically significant benefit in alleviating psychotic symptoms.
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Comparing Sequelae After Hospitalization with COVID-19, Influenza, or Sepsis
The incidence of most selected new-onset medical conditions did not significantly differ among those who had been hospitalized with COVID-19, influenza, or sepsis.
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Reconsidering Aspirin Therapy for Elderly Patients
A post-hoc analysis of the ASPREE trial revealed that in presumably healthy elderly subjects, taking low-dose aspirin daily over three years was associated with a significant drop in hemoglobin and ferritin levels vs. placebo, even when patients with major bleeding events were excluded.
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Social Determinants Play Outsized Role in Black/White Cardiovascular Health Gap
Lower income levels, less education, tighter insurance access raise risk for cardiovascular disease mortality.