Clinical Publication
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Long-Term Maintenance Therapy After Percutaneous Coronary Intervention
An extended six-year follow-up of the HOST-EXAM study revealed the consistent benefit of the primary endpoint of fewer major cardiovascular events and less bleeding with clopidogrel vs. low-dose aspirin monotherapy in post-percutaneous coronary intervention patients who were on dual antiplatelet therapy for one year.
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Sparsentan Tablets (Filspari)
Sparsentan can be prescribed to alleviate proteinuria in adults with primary immunoglobulin A nephropathy who are at risk of rapid disease progression — generally, a urine protein-to-creatinine ratio 1.5 mg/g or higher.
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When the Aortic Annulus Is Small, Does TAVR Valve Type Matter?
In this propensity-matched analysis of transcatheter aortic valve replacement (TAVR) registry patients with small aortic annuli, the hemodynamic advantage of self-expanding TAVR valves was not associated with better clinical outcomes compared with balloon-expandable valves up to five years.
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Does One Negative Troponin Measurement Rule Out Acute Coronary Syndrome?
Using a common clinical chest pain algorithm plus a point-of-care troponin measurement for low-risk patients, researchers reported significantly lower healthcare costs. Also, this approach did not seem to result in more major adverse cardiovascular events.
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Bleeding Risk with Combination Amiodarone and Direct-Acting Oral Anticoagulants
Among patients with atrial fibrillation who were taking a direct-acting oral anticoagulant, there was a significant association between major bleeding and amiodarone use within 60 days, but no association with amiodarone use longer than 60 days before the bleed.
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Unexpected Low Voltage on an ECG
A registry study of hypertrophic cardiomyopathy (HCM) patients and elite athletes in Italy revealed low voltage on ECG is not uncommon in HCM and may be a marker for more left ventricular scarring on cardiac imaging — and a poor prognosis.
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More Daily Steps Lowers Cardiovascular Disease Risk Among Older Adults
Researchers reported that for every additional 500 steps per day, the risk for heart disease, heart failure, and stroke declined by 14% among adults age 70 years and older.
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Multivitamin-Mineral Supplementation vs. Cocoa Extract for Cognition
This large, randomized trial followed participants for three years and determined that daily use of a cocoa supplement was not associated with cognitive enhancement in older adults, whereas a multivitamin supplement was associated with significant cognitive benefits.
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Vitamin D3, Omega-3, and Their Effects on Frailty in Older Patients
Data from a large, randomized trial that included 25,871 adults age 50 years or older indicated 2,000 daily units of vitamin D3 and 1 g daily of omega-3 fatty acid supplementation did not affect frailty.
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Mediterranean Diet Pairs Well with Immune Checkpoint Blockade
The popular healthy diet boosted response to unique cancer therapy among patients with advanced melanoma.