Clinical Publication
RSSArticles
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Can Bariatric Surgery Control Blood Pressure Long-Term?
A randomized trial comparing bariatric surgery to medical therapy in hypertensive obese patients has shown that bariatric surgery effectively lowers blood pressure over five years of follow-up.
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Doxycycline Reduces the Risk of C. difficile Infection in Patients Treated for CAP
In a retrospective study from the VA, doxycycline was associated with a lower risk of C. difficile infection compared to azithromycin in hospitalized patients with community-acquired pneumonia.
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Supplemental Calcium Therapy for the Prevention of Preeclampsia and Preterm Birth
In pregnancy, calcium supplementation was well tolerated and reduced the risk of preeclampsia and preterm birth, with no significant differences observed between low-dose and high-dose supplementation.
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Medications for OUD in the First Trimester and Congenital Malformation Risk
In this large, retrospective cohort study of births covered by Medicaid from 2000-2018, the authors used linked Medicaid use data to compare 9,514 pregnancies with buprenorphine exposure and 3,846 with methadone exposure in the first trimester. After adjusting for relevant confounders, the risk of major congenital malformation was lower for buprenorphine-exposed infants compared to methadone-exposed infants (risk ratio, 0.82; 95% confidence interval, 0.69-0.97), although rates overall remained low (50.9 per 1,000 for buprenorphine and 60.6 per 1,000 for methadone).
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New Guidelines on p16/Ki67 Dual Stain for Triage of HPV-Positive Cervical Cancer Screening Tests
This article outlines national consensus guidelines for the use of p16/Ki67 dual stain for triage of human papillomavirus-positive cervical cancer screening tests.
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Novel Combined Oral Contraceptives and VTE Risk: What Do We Know?
Recently, novel combined oral contraceptives containing estradiol valerate-dienogest, estetrol-drospirenone, and 17-beta estradiol with nomegestrol acetate have been released. Whether these types of estrogen are safer than ethinyl estradiol formulations in terms of venous thromboembolism risk is unknown.
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Is Artificial Intelligence Coming for Your Job?
A retrospective analysis of plain chest X-ray images in the medical record using deep learning in patients suitable for risk assessment for atherosclerotic cardiovascular disease (ASCVD) has shown similar results as the American College of Cardiology/American Heart Association ASCVD risk calculator for determining who is at sufficient risk to consider statin therapy.
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Can Pulmonary Artery Pressure Help in the Decision to Operate in Chronic Aortic Regurgitation?
A large tertiary center retrospective observational study of patients with moderate to severe aortic regurgitation showed that 14% had significant pulmonary hypertension (PH) and that it was associated with symptoms and higher mortality. Aortic valve replacement abrogated PH in most patients by hospital discharge and improved survival regardless of the presence of PH.
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Combined TAVR and LAAO Studied in a Randomized Controlled Trial
In this randomized controlled trial of patients with atrial fibrillation undergoing transcatheter aortic valve replacement (TAVR), concomitant left atrial appendage occlusion at the time of TAVR was noninferior to TAVR plus medical therapy for a combined endpoint of death, stroke, and major bleeding at two years.
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Another Hemodynamic Variant of Aortic Stenosis
A large, retrospective, observational study of patients with aortic valve gradients in the severe aortic stenosis range but with aortic valve areas in the moderate range has shown that such patients are not uncommon. Their prognosis is similar to patients with high-gradient severe aortic stenosis.