Clinical Publication
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Is It Past Time to Change Dietary Guidelines for Alcohol Use?
Analysis reveals that previous studies demonstrating the health benefits of moderate alcohol drinking were of low quality and that the relatively few published studies meeting the minimal quality criteria to avoid this problem do not show significantly lower mortality risk for moderate alcohol drinkers.
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CSF Analysis May Help in the Diagnosis of Dementia with Lewy Bodies
This paper demonstrated that cerebrospinal fluid (CSF) alpha-synuclein seeding assays can distinguish between clinically diagnosed dementia with Lewy bodies and controls, and that the presence of hyposmia with core clinical features had the highest predictive value of detecting CSF alpha-synuclein.
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Anchoring Alzheimer’s Disease Along an Amyloid Timeline
In 601 individuals from Wisconsin-based cohorts with amyloid-beta and tau positron emission tomography scans, the magnitude and topographical spread of tau pathology increased with longer duration of amyloid-beta positivity, and the cognitive decline was steepest in those with the longest duration of amyloid-beta positivity and elevated entorhinal tau.
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Clinical Criteria for a Limbic-Predominant Amnestic Neurodegenerative Syndrome
Predominant limbic degeneration in older geriatric patients (ages 75 years and older) with slowly progressive episodic memory loss with fluorodeoxyglucose-positron emission tomography medial temporal hypometabolism limbic-predominant age-related TDP-43 encephalopathy (LATE) involves a progressive degeneration of the amygdala, then hippocampus, then middle frontal gyrus.
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Can Large Vessel Strokes Be Treated with IV Thrombolysis in an Extended Time Window?
In this trial involving Chinese patients with ischemic stroke caused by large vessel occlusion, treatment with tenecteplase administered 4.5 to 24 hours after stroke onset resulted in less disability and similar survival compared to standard medical treatment.
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Incidental Cerebral Microinfarcts in Patients with Active Cancer
In this study of patients with active cancers, 3.6% had asymptomatic, incidental acute ischemic stroke lesions on magnetic resonance imaging and had three times the risk of having a subsequent clinical stroke in the next month.
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The Cath was “Clean!”
The featured electrocardiogram was obtained following successful resuscitation from cardiac arrest. Although echo done soon after showed akinesis of the anterior wall, no significant coronary narrowing was seen on cardiac catheterization. Can you explain? What is this phenomenon called?
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Donanemab-azbt (Kisunla)
The U.S. Food and Drug Administration has approved the third anti-amyloid beta monoclonal antibody for the treatment of Alzheimer’s disease, following aducanumab and lecanemab.
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Dengue Is Surging, Including in the Americas
Dengue is surging, and cases have been acquired in the United States, including in Puerto Rico and Florida.
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CVD Risk from Ketogenic Diets
A recent analysis of the UK Biobank data found that subjects on a low-carbohydrate, high-fat diet had higher levels of low-density lipoprotein cholesterol and apolipoprotein B, and an increase in incident major adverse cardiovascular events over a 12-year follow-up than subjects on a standard diet.