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An interesting therapeutic concept that has been put into clinical practice in the past several years is the use of nitric oxide donors for pulmonary hypertension.
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This report from the merlin-timi 36 investigators describes the effects of ranolazine on spontaneous arrhythmias in patients with acute coronary syndrome (ACS).
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Off-pump CABG avoids the complications of cardiopulmonary bypass (CPB), but is technically demanding.
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Cardiac death and perioperative myocardial infarctions occur in 2-20% (mean 6) of major noncardiac vascular surgery. Statins have been shown to have a protective effect, but the exact mechanism of this benefit is unclear.
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Lesley and colleagues analyzed a 5% national sample of Medicare inpatient, outpatient, and carrier files to examine the use of ICD therapy for both primary and secondary prevention of sudden cardiac death.
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Although ECG is the standard initial screening test for acute coronary syndromes, its value for the diagnosis of acute myocardial infarction (MI) is difficult to determine because of the vagaries of serum biomarkers.
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Exceptional attention has been paid to the recent publication of the COURAGE Trial (April 2007) regarding the efficacy of percutaneous coronary intervention (PCI) in stable coronary disease patients, whereas in acute coronary syndromes, including STEMI and unstable angina, there is reasonable consensus as to an interventional approach in patients with either PCI or CABG as opposed to medical therapy.
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Are thiazolidinediones safe? New study shows Zometa reduces risk of hip fractures and improves survival; Merck HIV vaccine proven ineffective in clinical trials; no causal association found between exposure to mercury from thimerosal; and FDA approvals.
