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The emergency treatment of patients with acute myocardial infarction (MI) with intravenous then oral beta-blockers has become the standard of care based upon randomized trials of over 27,000 patients. However, most of these trials were done before the advent of reperfusion therapy and aggressive platelet antagonists.
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For the past 3 decades, beta-blockers have been first-line therapy for hypertension. However, recently the efficacy of beta-blockers for treating primary hypertension has been challenged. Thus, Lindholm and colleagues from Sweden conducted a meta-analysis of 13 randomized, controlled trials for the treatment of primary hypertension where a beta-blocker was used in at least 50% of the patients.
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Given the impressive results of beta-blockers added to angiotensin-converting-enzyme (ACE) inhibitors in heart failure patients, many have suggested that had beta-blockers been studied first for heart failure, they would have been so impressive that we would start them before ACE inhibitors.
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FDA Recommends Approval of Muraglitazar, But May Need To Reconsider; Which Antipsychotics Are More Dangerous?; Should CPOE Undergo Evaluation?; New Treatment for Tennis Elbow; FDA Actions
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A recent journal of the American College of Cardiology contains a Focus Issue section, consisting of 3 articles about PROVE IT-TIMI 22 and a state of the art paper ...
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Colchicine added to conventional therapy for acute pericarditis reduced the recurrence rate and corticosteroids increased it.
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The majority of chronic stable coronary artery disease patients given 75 mg of EC aspirin daily have adequate inhibition of COX, but younger, heavier, and post MI patients may not.
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The newest generation spiral CT scanner with 64 slices, thin detectors and faster X-ray tube rotation provides high-resolution, near motion-free coronary artery images.
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In this paper, Malouf and colleagues from the Mayo Clinic looked at the significance of C-reactive protein (CRP) levels on the recurrence of atrial fibrillation or atrial flutter after a successful cardioversion.
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ICDs implanted by higher volume physicians are associated with lower rates of mechanical complications and infection.
