Clinical Cardiology
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Aspirin, Clopidogrel, or Both After Coronary Interventions?
A recent study of patients who had undergone a percutaneous coronary intervention and were transitioning from dual antiplatelet therapy to monotherapy showed clopidogrel was superior to aspirin for preventing further major adverse events, including bleeding. -
Age Drives Stroke Risk in Atrial Fibrillation
Among patients with newly diagnosed atrial fibrillation age 66-74 years without other CHA2DS2-VASc risk factors for thromboembolism, the older they are in this age range, the more likely they are to experience a stroke. -
Time of the Essence with Dapagliflozin for Heart Failure
By adding dapagliflozin to maximally tolerated standard therapy for heart failure with reduced left ventricular ejection fraction, researchers noted the reduction in mortality and recurrent heart failure began within one month of starting this therapy. -
Is a History of Palpitations Useful for Detecting Atrial Fibrillation?
An analysis of the utility of implanted loop recorders to detect subclinical atrial fibrillation in high-risk individuals showed that among common arrhythmia-compatible symptoms, only palpitation was predictive of discovering episodes of atrial fibrillation.
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Can Mitral Regurgitation Prevent Atrial Thrombosis Caused by Atrial Fibrillation?
A study of nonrheumatic patients with atrial fibrillation who were inadequately or not anticoagulated undergoing transesophageal echocardiography before cardioversion showed moderate-to-severe mitral valve regurgitation attenuates the risk of finding left atrial thrombi or spontaneous echo contrast and could be considered a thromboembolic risk modifier.
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Using His Bundle Pacing for Cardiac Resynchronization: Does It Hold Up to the Standard?
In a randomized trial of patients with heart failure and left bundle branch block, cardiac resynchronization therapy via permanent His bundle pacing produced similar short-term outcomes to traditional biventricular pacing, albeit with higher pacing thresholds.
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STEMI in Post-Transcatheter Aortic Valve Replacement Patients
This large series of post-transcatheter aortic valve replacement patients with ST-elevation myocardial infarction demonstrates elevated rates of percutaneous coronary intervention failure and high short- and intermediate-term mortality rates.
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Another Way Antibiotic Therapy Can Kill You
An analysis revealed fluoroquinolone antibiotic use was associated with later aortic diseases and mortality in patients without known aortic disease.
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Another Agent for Hypercholesterolemia
A pooled analysis of three randomized, controlled trials of inclisiran in patients with atherosclerotic cardiovascular disease or its risk equivalent showed impressive reductions in LDL cholesterol with subcutaneous injections every six months.
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Importance of Atherosclerotic Disease Risk Factors in Myocardial Infarction Patients
ST-elevation myocardial infarction patients without standard risk factors recorded a higher all-cause mortality rate that was particularly evident in women. Using proper therapy in these patients may attenuate this risk.