Clinical Briefs in Primary Care
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Initial Orthostatic Hypotension: An Under-Recognized Form of Orthostatic Hypotension
Initial orthostatic hypotension represents a population at risk for falls, which may be missed with traditional methods of orthostatic BP measurement.
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Delay in Diagnosis of Hepatocellular Carcinoma
Diagnostic delays are common among patients with hepatocellular carcinoma. -
A Glimmer of Hope for Beta-Blockers in Heart Failure from Diastolic Dysfunction
Because these data are observational in nature, they cannot definitively establish whether beta-blocker treatment reduces mortality in d-CHF, but they provide strong impetus to perform a large randomized trial to ultimately answer the question. -
Left Atrial Appendage Closure: Another Possible Interventional Fix for Atrial Fibrillation
Left atrial appendage closure may be another reasonable option for reduction of stroke risk in atrial fibrillation. -
Can You Make ‘Flat’ Basal Insulin ‘Flatter?’
For patients incurring problematic episodes of hypoglycemia, an insulin that provides even “flatter” plasma levels may provide an advantage.
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Treatment Choices Among the PDE5 Inhibitors
Patients may benefit from an opportunity to try more than one PDE5 inhibitor, but the differences between them are generally quite modest.
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The NOF Guideline on Prevention and Treatment of Osteoporosis
In persons with low BMD, guidelines suggest vertebral imaging dependent on age and other specific risk factors, such as low-trauma fracture during adulthood, height loss, or long-term steroid use.
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Treatment of Depression: Sometimes, It’s Hard to Beat Placebo
Clinical trials in major depression may benefit from attending to issues that tend to magnify placebo response.
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Reflections on the Consequences of Morning BP Surge
Study determined morning BP surge was associated with increase CV risk in Japanese, but not African-American, men.
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Does Hypovitaminosis D Increase Risk of Atrial Fibrillation in Hypertensive Patients?
Explanations for how vitamin D might be related to AFIB include the observation that activation of the renin-angiotensin-aldosterone system is heightened in vitamin D deficiency states.