Clinical Briefs in Primary Care
RSSArticles
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Manipulating the Microbiome to Enhance Metabolic Functions
The recognition that incretin secretion is impaired in type 2 diabetes stimulates consideration of a similar trial in diabetic patients.
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Confirming the Value of Total Knee Replacement
Total knee replacement provides better outcomes for pain, symptoms, activities of daily living, and quality of life than medical therapy alone.
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Is Breakfast the Most Important Meal of the Day?
Omission of breakfast was associated with less secretion of insulin and glucagon-like peptide and higher levels of free fatty acids, glucose, and glucagon.
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Leaving the Annual Physical Behind
To date, the annual physical has shown minimal, if any, benefit and potential for harm.
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Between-arm Differences in BP Predict Peripheral Arterial Disease
An inter-arm systolic blood pressure difference of as little as 10 mmHg was associated with a doubling of the risk for peripheral arterial disease.
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Uric Acid as a Predictor of Hypertension
Our currently defined levels of “normal” for uric acid may have to be reconsidered.
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ACE Inhibitors vs ARBs for Hypertension
This data review would support using angiotensin-converting-enzyme inhibitors preferentially over angiotensin II receptor blockers in most patients with hypertension.
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Difficult Choices in Long-term Osteoporosis Management
The greatest improvements in bone mineral density were seen in women who were assigned initially to a combination of denosumab and teriparatide and then switched to denosumab monotherapy.
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Dextromethorphan-Quinidine Combo for Alzheimer’s Patients with Agitation
The combination of dextromethorphan and quinidine appears promising for management of aggression in Alzheimer’s patients.
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Fixing Intractable Pruritus: Azathioprine
This retrospective study supports consideration of azathioprine when other efficacious treatments have been exhausted.