Clinical Briefs in Primary Care
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Can Antibiotic Exposure Cause Some Mood Disorders?
Since gut flora alteration through antibiotic administration is a commonplace experience for most adults, might such exposures, by altering the intestinal microbiome, also be associated with mood disorders in humans?
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Systemic Markers of Hidradenitis Suppurativa
Measurement of C-reactive protein, an inexpensive and readily available test, in hidradenitis patients may enhance assessment of disease severity.
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Expanding Safe Prescribing for Metformin
In an era of progressively more expensive interventions for type 2 diabetes, clinicians may wish to re-evaluate the boundaries of safe prescribing for metformin.
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Potential Benefits of Down Titration Through Inhaled Steroid Discontinuation
The likelihood of serious pneumonia was reduced by 37% in patients who discontinued inhaled corticosteroids vs those who did not.
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Prostate Cancer Screening: Have Clinicians Been Listening?
Published modeling methods suggest an increase in prostate cancer mortality by omission of universal screening; to date, that has not been the case, but may require a longer window of observation before reaching definitive conclusions.
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Vitamin D: Conclusions From an NIH Conference
Observational studies indicate that low vitamin D status is associated with risk for cardiovascular disease, cancer, diabetes, and other important disorders, but whether this relationship is causal is not yet known, and whether correction of such a causal relationship (if established) will improve outcomes remains to be determined.
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Good Cardiovascular News from the SGLT2 Inhibitor Class?
The widely celebrated results of a recent landmark trial give at least one physician reasons to pause.
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Spironolactone Best Add-on for Resistant Hypertension
Spironolactone provided statistically significant greater reductions in blood pressure than two other active agents.
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Bisphosphonates May Impact Bone Recurrence in Postmenopausal Women with Breast Cancer
Although the rate of distant recurrence and breast cancer mortality were statistically and significantly superior in women who had been treated with bisphosphonates, the absolute degree of benefit was of dubious clinical relevance.
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No Payoff to Physical Therapy After Healed Ankle Fracture
After successful healing of an ankle fracture, a program of supervised physical therapy does not appear to improve outcomes.