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Optimal treatment for carcinoma of unknown primary has not been established. In a multicenter, randomized Phase II trial, 66 patients were treated with cisplatin, gemcitabine and either paclitaxel or vinorelbine.
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Immediate breast reconstruction after mastectomy has intuitive appeal, but concern has been raised that such an approach hinders postmastectomy radiotherapy.
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Breast cancer patients who received either high-dose, standard-dose or no chemotherapy were studied prospectively, utilizing a comprehensive battery of neuropsych tests.
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An increasing number of active therapies have become available for multiple myeloma in addition to high dose chemotherapy followed by autologous transplant (ASCT).
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Patients with coronary artery disease who have received intra-coronary, drug-eluding stents (DES) may benefit from longer courses of clopidogrel than is currently standard.
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Breast cancer in young women is uncommon, but when it does occur, it is thought to be very aggressive. In this large series of young (< 35 years old) patients from a single institution seen over a 13-year period, high tumor grade, hormone receptor negativity, and family history of ovarian cancer turned out to be significant negative prognostic indicators.
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Artificial hydration therapy could alleviate membranous dehydration signs, but could worsen peripheral edema, ascites, and pleural effusions. It is suggested that the potential benefits of artificial hydration therapy should be balanced with the risk of worsening fluid retention symptoms.
