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The preoperative use of angiotensin-converting enzyme inhibitors (ACEI) with coronary artery bypass graft (CABG) surgery is controversial. Thus, these investigators from the United Kingdom performed a retrospective, observational study of patients undergoing isolated CABG who did not have cardiogenic shock.
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In this paper, Packer et al report on the modes of death in patients in the Sudden Cardiac Death-Heart Failure Trial (SCD-HeFT).
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The optimal duration for dual anti-platelet therapy (DAT) after drug-eluting stent (DES) implantation remains unknown.
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Yu et al report a multi-center trial evaluating the relative benefits of right ventricular apical pacing compared to biventricular pacing in patients with a standard indication for pacing and a baseline preserved left ventricular ejection fraction.
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Statin and niacin increase HDL-C, omeprazole reduces effectiveness of clopidogrel, darbe-poetin increases risk of stroke, statins decrease risk of gallstone disease, FDA Actions
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Anticoagulation during percutaneous coronary intervention (PCI), although necessary to prevent thrombus formation on the interventional equipment, can lead to significant morbidity from bleeding complications, particularly if the dosage is excessive.
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Intensive lipid lowering with statin therapy (atorvastatin 80 mg) in patients presenting with acute coronary syndromes (ACS) resulted in improved outcomes compared to treatment with moderate lipid lowering (pravastatin 40 mg) in the PROVE-IT TIMI-22 study (Cannon et al. N Engl J Med.
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Two recent studies have demonstrated the bene-ficial effects of nicotinic acid (niacin) on carotid artery atherosclerosis.
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