Cardiology
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Low TMAO for a Healthy Heart
The gut microbial metabolite trimethylamine N-oxide (TMAO) is a predictor of coronary artery disease (CAD). Long-term changes in TMAO is a predictor of CAD and speaks to the benefits of a plant-based diet to prevent heart disease.
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Cholesterol Levels and Predicted Survival Rates Among Elderly Women
Researchers found neither low levels of high-density lipoprotein nor high levels of low-density lipoprotein were associated with predicted survival in older women. This finding is consistent with other studies of cholesterol and mortality in the elderly.
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Cannabis for Mental Health Disorders: Follow the Evidence
In a review of 83 eligible studies, researchers found little evidence to support the efficacy of cannabinoids to treat depressive disorders, anxiety disorders, or several other mental health disorders. There is low-grade evidence that pharmaceutical cannabis may help improve symptoms of anxiety in patients with a comorbid medical condition.
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Incidence of Cardiovascular Disease and All-Cause Mortality: Does the Type of Meat Consumed Matter?
Investigators found consuming more processed meat, unprocessed red meat, or poultry (but not fish) was closely connected to a higher risk for incident cardiovascular disease. Meanwhile, consuming processed meat or unprocessed red meat (but neither fish nor poultry) was strongly associated with a higher risk of all-cause mortality.
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Cannabis in the Treatment of Headache and Migraine
The authors of this observational study found nearly a 50% reduction in self-reported headache and migraine severity following use of inhaled medicinal cannabis.
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Pressure Support vs. T-Piece Trials for Successful Extubation: An End to the Controversy?
In a randomized clinical trial of 1,153 adults who were ready for weaning after at least 24 hours of mechanical ventilation, researchers found that a spontaneous breathing trial with 30 minutes of pressure support ventilation compared with two hours of T-piece ventilation led to significantly higher successful extubation rates.
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Critical Care in the Obese Patient
This article will highlight some important practical aspects of care that arise in the management of critically ill obese patients, along with the unique physiology resulting from obesity.
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Bempedoic Acid (Nexletol)/Bempedoic Acid and Ezetimibe (Nexlizet)
Bempedoic acid and bempedoic acid/ezetimibe should be prescribed as a supplement to diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who need additional LDL-C lowering.
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Heart Rate and Diastolic Blood Pressure in Chronic Aortic Regurgitation Patients
A retrospective observational study of patients with moderate to severe aortic regurgitation showed the independent predictive value of diastolic blood pressure and resting heart rate for all-cause mortality under medical management.
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Using Apple Cider Vinegar for Weight Management on a Restricted Diet
Supplementation with 30 mL of apple cider vinegar combined with a restricted calorie diet may lower body weight, body mass index, and serum triglyceride levels in people with obesity.