Cardiology
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MUCH Ado About WUCH
In a long-term, fixed-drug therapy of hypertension study, masked uncontrolled and white coat uncontrolled hypertension exhibited poor reproducibility over four years. This calls into question studies showing higher rates of adverse outcomes with one baseline blood pressure assessment used to categorize patients.
Thin Evidence Supporting the Obesity Paradox in STEMI
This largest-to-date analysis of six randomized studies of ST-elevation myocardial infarction revealed no association between body mass index and infarct size, one-year mortality, or heart failure hospitalization.
Benefits of Exercise in Established Atrial Fibrillation
A large, long-term, prospective, Norwegian population study of patients with established atrial fibrillation revealed physical activity at or above recommended levels reduces all-cause and cardiovascular mortality vs. atrial fibrillation patients who are inactive.
Warfarin vs. DOAC for Left Ventricular Thrombi
A large, multicenter, observational study of the relative efficacy of warfarin vs. direct oral anticoagulants (DOACs) for left ventricular thrombi has shown that DOAC use is associated with a higher risk of embolic events than warfarin. Investigators advised caution with off-label use of DOACs.
Does Anticoagulant Therapy Affect Outcomes in Left Ventricular Mural Thrombus Patients?
Left ventricular thrombus is an uncommon finding but one associated with a high incidence of all-cause mortality and major adverse cardiac and embolic events. Total regression of left ventricular thrombus on anticoagulant therapy reduced mortality.
Acute Myocardial Infarction, or Acute Pericarditis?
The lack of significant Q waves, lack of any reciprocal ST depression, and the prominent J-point notching in the figure all suggest this may not be an acute infarction.
Ozanimod Capsules (Zeposia)
Ozanimod should be prescribed to treat relapsing multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
Cannabis for Mental Health Disorders: Follow the Evidence
In a review of 83 eligible studies, researchers found little evidence to support the efficacy of cannabinoids to treat depressive disorders, anxiety disorders, or several other mental health disorders.
The Cascade Effect: Calcium Channel Blockers and High Blood Pressure
Many older adults who are prescribed calcium channel blockers subsequently receive a loop diuretic. Awareness of this common cascade may reduce unnecessary prescribing and potential harm.
More Mediterranean Diet Benefits: Diverse Microbiomes, Better Health Among Seniors
A randomized, multicenter study showed that eating a Mediterranean diet for one year improved the diversity of the gut microbiome in older subjects and was associated with reduced frailty and better health.