Cardiology
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Hyperdynamic Left Ventricular Function: Good or Bad News?
A large population study has shown a U-shaped relationship between left ventricular ejection fraction (EF) and mortality, with a nadir at 60-65%. The authors identified a new group at high risk for death: those with an EF ≥ 70%.
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Osilodrostat Tablets (Isturisa)
Osilodrostat should be prescribed to adult patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative.
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Cannabis in the Treatment of Headache and Migraine
The authors of this observational study found nearly a 50% reduction in self-reported headache and migraine severity following use of inhaled medicinal cannabis.
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Warfarin or DOACs for Atrial Fibrillation in Chronic Kidney Disease?
A large outpatient observational study of patients with atrial fibrillation and chronic kidney disease who were anticoagulated revealed that, compared to warfarin, direct oral anticoagulants exhibited less all-cause mortality and major bleeding with at least equivalent efficacy at preventing stroke.
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Anatomic vs. Functional Testing in Older Coronary Artery Disease Patients
An analysis of the PROMISE trial by age showed cardiovascular death or myocardial infarction was predicted by a positive stress test in patients with symptoms suggesting myocardial ischemia who were > age 65 years.
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Pharmacotherapy Considerations for COVID-19
A summary of selected pharmacotherapy options proposed to treat COVID-19.
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This ECG Was in Your ‘Pile to be Read’
Imagine the ECG in the figure was one of many tracings you received to read from a group of patients seen by other providers in your clinic. Unfortunately, no clinical information about this patient was available. How would one interpret this tracing? Considering no clinical information regarding what happened to the patient was available, what is the next step?
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Rimegepant Orally Disintegrating Tablet (Nurtec ODT)
Rimegepant should be prescribed to treat acute migraine with or without aura in adults.
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Diagnostic Criteria for Small Fiber Neuropathy
Multiple clinical tools have emerged to assess small fiber nerve dysfunction, but validated diagnostic criteria are needed to optimize diagnostic sensitivity, support clinical management, and facilitate patient selection for clinical trials.
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Home Oral Factor Xa Inhibitor Treatment for Pulmonary Embolism
Low-risk pulmonary embolus patients discharged in < 48 hours on rivaroxaban recorded a nominal three-month rate of recurrent emboli or major bleeding, suggesting such patients do not need to be hospitalized for treatment of pulmonary emboli.