Cardiology
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Fostemsavir Extended-Release Tablets (Rukobia)
Fostemsavir is indicated, with other antiretrovirals, to treat HIV-1 infections in heavily treatment-experienced adults with multidrug-resistant HIV-1 infections who are failing current regimens.
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COVID-19 and Steroids: Is There a Consensus?
A study of adults admitted with COVID-19 pneumonia revealed risk factors associated with developing acute respiratory distress syndrome (ARDS) and progression from ARDS to death included older age, neutrophilia, organ dysfunction, and coagulation derangement.
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Inappropriately Broad Empiric Antibiotics, Higher Mortality, and Community-Onset Sepsis
A retrospective cohort study revealed broad-spectrum antibiotics were unnecessarily prescribed to patients with community-onset sepsis and were associated with worse outcomes and higher mortality.
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Thin Evidence Supporting the Obesity Paradox in STEMI
This largest-to-date analysis of six randomized studies of ST-elevation myocardial infarction revealed no association between body mass index and infarct size, one-year mortality, or heart failure hospitalization.
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DASH Is Revisited and Updated, Lowering Subclinical Cardiac Injury Markers
In individuals without pre-existing cardiovascular disease, the Dietary Approaches to Stop Hypertension diet plan and a diet consisting of fruits and vegetables, given over eight weeks, lowered biomarkers for cardiac strain and injury.
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The Relationship Among Step Count, Step Intensity, and Mortality in Adults
The authors of this observational study of 4,840 adults show an association between higher number of steps taken daily and lower all-cause mortality, lower mortality from cardiovascular disease, and lower mortality from cancer, but no association between intensity of steps and mortality in any of those areas.
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COVID-19 and Steroids: Is There a Consensus on the Controversy?
A retrospective, single-center cohort study among 201 adults admitted with COVID-19 pneumonia revealed that risk factors associated with the development of acute respiratory distress syndrome (ARDS) and progression from ARDS to death included older age, neutrophilia, organ dysfunction, and coagulation derangement. Treatment with methylprednisolone may be beneficial for these patients.
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First-Pass Success Rate Between Rocuronium and Succinylcholine in Emergent Out-of-Hospital Endotracheal Intubation
This randomized, single-blind, noninferiority trial compared rocuronium and succinylcholine for rapid sequence intubation. Rocuronium was noninferior to succinylcholine with respect to the primary endpoint of first-pass intubation success.
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Improving Sepsis Outcomes: Raising the Bar
In addition to compliance with the sepsis bundles, how can critical care providers revolutionize and individualize sepsis care for optimal results?
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Sports Participation with Isolated Bicuspid Aortic Valve
If they follow recommendations for restriction from competitive sports, more than one-third of children and young adults with isolated bicuspid aortic valves could be disqualified mainly for mild aortic dilatation.