Cardiology
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ORANGES and ACTS Trials: No Mortality Benefit with Ascorbic Acid, Thiamine, and Hydrocortisone in Septic Shock Patients
Two double-blinded, placebo-controlled, randomized trials involving 337 patients (ORANGES, n = 137; ACTS, n = 200) with sepsis and septic shock have shown that administration of ascorbic acid, thiamine, and hydrocortisone did not reduce organ dysfunction or improve overall mortality. However, both trials showed that this combination therapy was effective in reducing the time to achieve shock resolution or shock-free days.
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Study: Few Black Adults Taking Proper Medicine for Difficult-to-Treat Hypertension
Black patients may not receive the right medications or proper lifestyle counseling.
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Does BAMI Spell the End for Cell-Based Therapy After Acute Myocardial Infarction?
Investigators tested the mortality benefit of intracoronary bone marrow cells in patients with successfully reperfused acute myocardial infarction. They observed no effect on mortality.
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Pulmonary Artery Denervation: A Promising Treatment Option for CTEPH
A trial of patients with residual chronic thromboembolic pulmonary hypertension following pulmonary endarterectomy showed pulmonary artery denervation is superior to medical management with riociguat.
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When Aortic Stenosis Is Almost Severe: What Happens Next?
A study of patients with normal flow, low gradients, normal left ventricular systolic function but with calculated aortic valve areas <1.0 cm2 showed that about half of them progressed to severe aortic stenosis during the 25-month median follow-up period.
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Perioperative Atrial Fibrillation: Is It Important?
A large epidemiologic study with validated endpoints of patients with atrial fibrillation after non-cardiac surgery demonstrated such patients experience a higher incidence of subsequent atrial fibrillation, stroke, transient ischemic attacks, and all-cause mortality over five years of follow up.
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Management of Cardiac Arrest Patients Without STEMI
Since there were no significant differences in outcomes at 90 days or one year, coronary interventions in successfully resuscitated cardiac arrest patients without evidence of STEMI or cardiogenic shock can be delayed until neurologic recovery is evident.
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Teprotumumab-trbw Injection (Tepezza)
Teprotumumab should be prescribed to treat thyroid eye disease.
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‘Hygiene Theater’
In a study of surfaces contaminated by an actual patient, no viable virus could be found. Similar studies of common community coronavirus found the virus survived less than one to three hours after drying on various surfaces, including surgical gloves and aluminum. People’s fears have been exaggerated by bad science and worse public policy.
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DASH Is Revisited and Updated, Lowering Subclinical Cardiac Injury Markers
In individuals without pre-existing cardiovascular disease, the Dietary Approaches to Stop Hypertension diet plan and a diet consisting of fruits and vegetables, given over eight weeks, lowered biomarkers for cardiac strain and injury.