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Statin use among cancer patients with diverse malignancies is associated with reduced cancer-related mortality. The mechanism is plausible since statins inhibit cholesterol synthesis, which reduces the pool of compounds necessary in cellular proliferation and maintenance of critical cellular functions, such as membrane integrity, signaling, protein synthesis, and cell cycle progression. Prospective clinical trials are warranted.
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This retrospective study of hospitalized patients receiving ceftriaxone found that additional treatment with doxycycline compared to other antibiotics was associated with a lower risk of Clostridium difficile infection.
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MRI scan was unable to discriminate between patients with favorable outcome and those with an unfavorable outcome when conducted at 1-year follow-up in patients who were treated for sciatica and disk herniation.
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The decision to choose a mechanical or a tissue valve for patients undergoing surgical aortic valve replacement (AVR) is a complex one that involves synthesizing clinical factors such as risk of bleeding, likelihood of reoperation, and patient preference. Increasingly, older patients with more comorbidities are being referred for AVR surgery.
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Many patients need to take long-term oral anticoagulants (OAC) for indications such as atrial fibrillation (AF) or mechanical prosthetic valves.
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Guideline-driven earlier mitral valve repair for patients with mitral regurgitation (MR) due to degenerative disease has increased in the last 25 years.
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Beta-blockers and noncardiac surgery; prenatal medication exposure and risk of autism; reasons for statin discontinuations; and FDA actions.
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