Cardiology
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TAVR Outcomes in Patients on Chronic Corticosteroid Therapy
A 12-year experience with transcatheter aortic valve replacement at one Paris hospital demonstrated chronic systemic corticosteroid use increases the incidence of major 30-day complications and all-cause mortality at one year.
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When Is TAVR Futile?
A study of all patients who underwent transcatheter aortic valve replacement over eight years in France was used to develop a futility score that would help predict who would not live one year after the procedure. This simple clinical score based on comorbidities predicted who would live one year with 95% specificity.
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Ticagrelor in the Elderly: More Potent Platelet Inhibition Not Always Better
In a study of 14,000 elderly patients with acute myocardial infarction, treatment with ticagrelor was associated with higher risks of bleeding and all-cause death vs. clopidogrel.
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Which Acute Myocardial Infarction Patients Need a Blood Transfusion?
A randomized trial of a restrictive blood transfusion strategy vs. a more liberal strategy in patients with acute myocardial infarction and anemia showed the restrictive strategy is noninferior to the liberal strategy for preventing the primary outcome of death, reinfarction, stroke, or emergency revascularization.
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Pralsetinib Capsules (Gavreto)
Pralsetinib should be prescribed to treat adults with metastatic RET, fusion-positive non-small cell lung cancer.
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Nuts and Heart Health
Investigators studied changes in quantity of nut consumption and relative risk of cardiovascular disease, finding significantly lower risk when nut consumption increases by > 0.5 servings daily.
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Repeat SARS-CoV-2 Infection
Whole genome sequencing confirmed that repeat infection with SARS-CoV-2 is possible, something that is consequential for vaccine use and public health.
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Dexamethasone for COVID-19 Inpatients Requiring Oxygen
Dexamethasone administration is associated with reduced 28-day mortality in oxygen-requiring COVID-19 patients, including those receiving mechanical ventilation.
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Vitamin D Deficiency and COVID-19 Infection
Investigators found the relative risk of testing positive for COVID-19 was higher for patients who likely are vitamin D deficient.
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Intermittent Fasting, Pesco-Mediterranean Diet Can Improve Health
Meta-analysis reveals pattern of better cardiovascular health among those who consume more seafood, vegetables, and fruit vs. those who live on red meat-heavy diets.