Cardiology
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Healthcare Workers with COVID-19 Antibodies: Strong Protection Against Reinfection
A study of healthcare workers demonstrated the presence of antibody to SARS-CoV-2 spike protein or to nucleocapsid provides strong protection against infection for up to six months.
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THC-Related Neuropsychiatric Symptoms in Older Adults
Using cannabis-based medicine often exposes patients to delta-9-tetrahydrocannabinol (THC), which is associated with psychotic symptoms. THC also can cause lightheadedness, dizziness, and thinking or perception disorder in older adults.
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Low BNP Levels in Up to 16% of Heart Failure Patients
In patients with clinical heart failure and low B-type natriuretic peptide levels, the authors found these patients usually are young and obese, with higher ejection fraction and better renal function.
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PFO Closure for Resistant Migraines: Finding an Elusive Link
A meta-analysis of two randomized trials of patent foramen ovale closure in resistant migraine showed a significant benefit in three of four clinical endpoints.
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Intracranial Plaque Rupture and Stroke
An MRI study of cerebral circulation in patients with embolic stroke of undetermined etiology showed evidence of atherosclerotic plaque in most patients, supporting the theory that unstable intracranial artery plaques play an etiologic role in embolic stroke.
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Can Left Ventricular Strain Detect Early Cardiac Toxicity of Cancer Chemotherapy?
Using left ventricular peak systolic global longitudinal strain vs. left ventricular ejection fraction to survey patients undergoing potentially cardiotoxic chemotherapy with at least one other risk factor for heart failure showed no difference in the primary endpoint of the difference in ejection fraction between the two groups at one year.
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Is Empagliflozin Safe in Combination with a Neprilysin Inhibitor for Heart Failure?
A prespecified subgroup analysis of heart failure patients with reduced ejection fraction who were on neprilysin inhibitors before empagliflozin was administered (vs. those not on neprilysin inhibitors) showed the reduction in mortality and hospital admissions for heart failure were not attenuated by concurrent neprilysin use.
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Acute Myocardial Infarction, or Related to COVID-19?
The ECG in the figure was obtained from a man in his 30s. How would one interpret this tracing if told the patient’s only symptom was recent shortness of breath on exertion that he had not experienced?
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Vericiguat Tablets (Verquvo)
Vericiguat is indicated to lower the risk of cardiovascular death and heart failure hospitalization in adults with symptomatic chronic heart failure and an ejection fraction less than 45%.
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Is There an Ideal Time to Administer Antihypertension Medications?
Taking all antihypertensive agents before bed vs. upon awakening in hypertensive patients showed there was less hypertension during sleep and few cardiovascular events over a six-year follow-up.