Cardiology
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Herpes Zoster Vaccine: Effective but Underused
The adjuvanted recombinant herpes zoster vaccine is highly effective in practice, but it is vastly underused.
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Antibiotics: Less Is Better, Sometimes
In England, and likely in many other areas of the world, antibiotics are given for longer than necessary. Excessively long durations of antibiotic use do not help patients and risk leading to more resistant infections.
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Is Empagliflozin Safe in Combination with a Neprilysin Inhibitor for Heart Failure?
A prespecified subgroup analysis of heart failure patients with reduced ejection fraction who were on neprilysin inhibitors before empagliflozin was administered (vs. those not on neprilysin inhibitors) showed the reduction in mortality and hospital admissions for heart failure was not attenuated by concurrent neprilysin use.
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Accounting for Patient Preference, Cardiovascular Disease Risk in Statin Therapy
Researchers weighed patient preferences and risks regarding statin therapy after reviewing 10-year atherosclerotic cardiovascular disease risk scores.
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Is Metformin a Wonder Drug?
An analysis of patients taking metformin for diabetes showed they were less likely to report back, knee, neck/shoulder, or multisite musculoskeletal pain.
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Another Agent for Hypercholesterolemia
A pooled analysis of three randomized, controlled trials of inclisiran in patients with atherosclerotic cardiovascular disease or its risk equivalent showed impressive reductions in LDL cholesterol with subcutaneous injections every six months.
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Importance of Atherosclerotic Disease Risk Factors in Myocardial Infarction Patients
ST-elevation myocardial infarction patients without standard risk factors recorded a higher all-cause mortality rate that was particularly evident in women. Using proper therapy in these patients may attenuate this risk.
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Efficacy of the Ross Procedure in Young Adults with Aortic Valve Disease
Young patients who underwent the Ross procedure recorded high rates of survival and low rates of reintervention long term.
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ECG Abnormalities in Elite Male and Female Athletes
A study of elite international soccer athletes of both sexes revealed women more often recorded what would be considered abnormal ECGs — only to return normal echocardiograms. This knowledge is especially valuable when treating those who have recovered from COVID-19.
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New Treatment for Postural Orthostatic Tachycardia Syndrome
A study of ivabradine in patients with the common hyperadrenergic subtype of the postural orthostatic tachycardia syndrome led to slower standing heart rates, lower plasma norepinephrine levels, and improved quality of life after one month.