Cardiology
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Exercise Intervention for Improving Metabolic-Associated Fatty Liver Disease
Researchers assessed the histological appearance of liver biopsies from patients with metabolic-associated fatty liver disease (MAFLD) who completed 12 weeks of structured and supported aerobic exercise. Compared to biopsies from a nonexercising control group, the intervention arm demonstrated some reversal of histopathologic changes caused by MAFLD.
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Intracranial Plaque Rupture and Stroke
An MRI study of cerebral circulation in patients with embolic stroke of undetermined etiology showed evidence of atherosclerotic plaque in most patients.
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Ketogenic Diet Improves Cognition, Daily Function in Alzheimer’s Disease Patients
In a randomized, crossover trial, patients with Alzheimer’s disease on a ketogenic diet for 12 weeks demonstrated improved cognition, daily function, and quality of life.
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Transdiagnostic Cognitive Behavioral Therapy in Young Patients
This Danish randomized clinical trial compares a new form of cognitive behavioral therapy delivered in a community setting to “treatment as usual” for children and teens with emotional problems and shows advantages in multiple arenas, including parent-reported changes in child distress and impairment.
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Air Filters and Asthma
Asthmatic children showed improved small airway mechanics following indoor filtration of particulates (2.5 µm and greater) using high-efficiency particulate air filtration devices.
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Loneliness and Type 2 Diabetes Incidence
Loneliness appears to be an independent risk factor for type 2 diabetes, although further research to identify the causal relationship between loneliness and type 2 diabetes development is needed.
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Rapid Intermittent Bolus of Hypertonic Saline May Be a Better Way to Correct Symptomatic Hyponatremia
In this randomized clinical trial, hypertonic saline given via rapid intermittent bolus therapy was as effective and safe as slow continuous infusion, and was associated with a lower rate of recorrecting treatment and higher efficacy in achieving goal sodium within one hour.
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Using Procalcitonin to Limit Antibiotic Treatment for Sepsis Reduces Infection-Related Adverse Events
By shortening the duration of antibiotic therapy, a procalcitonin-guided protocol decreased the rate of infection-associated adverse effects, decreased costs, and reduced mortality in patient with sepsis.
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Post-COVID-19: The Crisis After the Crisis
Critical care physicians have the opportunity to optimize long-term function and quality of life for COVID-19 survivors. It is paramount to prevent, recognize, and treat post-COVID-19 symptoms.
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Dasiglucagon Injection (Zegalogue)
Dasiglucagon should be prescribed to treat severe hypoglycemia in pediatric and adult patients (≥ age 6 years).