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This prospective multicenter observational study demonstrates that patients with do-not-intubate (DNI) status who receive non-invasive positive pressure ventilation (NPPV) for respiratory failure have high hospital mortality. Presence of cough, being awake, or having a primary diagnosis of COPD or CHF, is associated with improved outcome.
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Neurologic emergencies of pregnancy range from life-threatening conditions such as eclamptic seizures to self-limiting disorders like meralgia paresthetica. This discussion will include those neurologic disorders directly resulting from pregnancy or the puerperium, those that are pre-existing conditions but now affect the pregnant patient or are affected by the gravid state of the patient, and those disorders that are not directly related to the pregnancy but may first become apparent during the gravid state.
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The most commonly prescribed statins have a low incidence of rhabdomyolysis, according to the results a new study of more than 250,000 patients.
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RSD1235 shows promise as an agent for the management of atrial fibrillation.
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Chronic apical right ventricular pacing in patients with congenital heart block is associated with late findings consistent with deleterious left ventricular remodeling.
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The addition of niacin to patients with known coronary artery disease on statins raised HDL cholesterol and reduced atherosclerosis progression.
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The 6 articles in the December 1, 2004, issue of JAMA represent a detailed overview of drug safety in the United States. The withdrawal of cerivastatin reflects the current situation, and problems with antidepressants in youngsters and, more recently, the identification of adverse reactions with the 3 Cox-2 inhibitors, raise important questions regarding the ability of the FDA to effectively police adverse drug reactions after release of a drug.