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The FDA is requiring the manufacturers of metoclopramide (Reglan®) include a boxed warning on their labeling regarding the risk of long-term or high-dose use and tardive dyskinesia.
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Modafinil (Provigil®) is a wake-promoting medication used to treat narcolepsy and other sleep disorders.
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What is the best dose of aspirin for patients taking dual therapy with clopidogrel to prevent cardiovascular events?
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Increasing evidence suggests that proton pump inhibitors (PPIs) may attenuate the effect of clopidogrel on platelet aggregation.
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Some natural products are not so "natural" after all.
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Since the risk of gastrointestinal bleeding is increased when clopidogrel is added to aspirin therapy in patients with acute coronary syndromes (ACS), many prescribe proton-pump inhibitors (PPIs) to reduce this risk. However, mechanistic studies suggest that PPIs may reduce the effectiveness of clopidogrel.
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Whether oral vitamin K reduces the risk of bleeding related to excessive anticoagulation from warfarin remains unclear.
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In this study of physician use of clinical information technology in relation to 4 common diagnoses in 41 urban hospitals in Texas, inpatient outcomes were better the more extensive the use of computerized order entry, test results, physician charting, and decision support. Increased use of IT was also associated with significantly lower costs for all hospital admissions.
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Dronedarone is a new antiarrhythmic drug with structural similarities to amiodarone. During development of the molecule, the steps included removal of the iodine atoms and making the compound more lipophilic; the latter produces a shorter elimination half-life and reduced tissue accumulation.