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The antiplatelet effect of clopidogrel is dependent upon its conversion and activation through the 2C19 pathway of the P450 system. Blockade of this pathway occurs because of genetics, in persons who do not have sufficiently active 2C19, and pharmacotherapies that specifically block 2C19. Proton pump inhibitors (PPIs), particularly omeprazole, are recognized to be 2C19 inhibitors. Is there reason for concern?
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Cholinesterase inhibitors place patients at risk for syncope, bradycardia, permanent pacemaker insertion, and hip fracture.
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Low levels of serum 25-hydroxyvitamin D [25(OH)D] in non-institutionalized older adults were associated with future increased mortality from all causes and from cardiovascular disease.
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Although health care providers have a major influence on their patients when they decide to undergo screening for prostate cancer, shared decision making often does not occur despite recommendations.
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Recombinant Panton-Valentine leukocidin (PVL) toxins showed lytic activity against human (but not murine) neutrophils. The lytic activity of culture supernatants of USA400 and USA300 strains of MRSA were completely neutralized by anti-PVL monoclonal antibodies. In contrast, phenol-soluble modulin alpha3 (PSM) failed to lyse human neutrophils but did enhance PVL-mediated neutrophil lysis.
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This retrospective cohort study reaffirms the link between hyperglycemia and mortality in the ICU, but demonstrates that the risk does not apply equally to all patient groups and, instead, varies based on admission diagnosis.
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Many clinical trials have confirmed the benefit of early invasive therapy for high-risk patients presenting with acute coronary syndromes (ACS). However, the optimal timing of cardiac catheterization in this group remains unknown.
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