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For the past 3 decades, beta-blockers have been first-line therapy for hypertension. However, recently the efficacy of beta-blockers for treating primary hypertension has been challenged. Thus, Lindholm and colleagues from Sweden conducted a meta-analysis of 13 randomized, controlled trials for the treatment of primary hypertension where a beta-blocker was used in at least 50% of the patients.
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Given the impressive results of beta-blockers added to angiotensin-converting-enzyme (ACE) inhibitors in heart failure patients, many have suggested that had beta-blockers been studied first for heart failure, they would have been so impressive that we would start them before ACE inhibitors.
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FDA Recommends Approval of Muraglitazar, But May Need To Reconsider; Which Antipsychotics Are More Dangerous?; Should CPOE Undergo Evaluation?; New Treatment for Tennis Elbow; FDA Actions
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Arthritis and exercise. Altern Med Alert 2006;9(suppl 7):S1-S2.
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Greenfield RH. Policosa--no? Altern Med Alert 2006;9(7):83-84
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Udani J, et al. Chromium for Type 2 diabetes mellitus and weight loss. Altern Med Alert 2006;9(7):78-83.
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Partial Liquid Ventilation (PLV) with Perfluorocarbon (PFC) has been demonstrated in animal models of acute lung injury to recruit dependent lung regions (the so-called "liquid PEEP" effect), to redistribute blood flow to better ventilated regions, to thus improve gas exchange compared with conventional ventilation, and also to facilitate the clearance of retained secretions.
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A prospective, multi-center randomized trial was performed to determine the feasibility of the semirecumbent position (goal, head of bed elevation [HOB] 45°) and its impact on the incidence of ventilator-associated pneumonia (VAP).
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