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Most patients with ST-elevation myocardial infarction (STEMI) present to hospitals that are not capable of percutaneous coronary intervention (PCI). Rapid transfer to PCI-capable facilities for primary PCI may result in earlier reperfusion of the infarct artery and better clinical outcomes. However, delays in transfer may diminish the mortality benefit achieved with primary PCI in STEMI.
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This basic science paper explores the role of the tumor microenvironment in the development of tumor resistance to chemotherapy. Two distinct fatty acid molecules, endogenously produced by cancer cells in response to platinum-based chemotherapy drugs, were found to confer significant tumor chemoresistance. Remarkably, these two fatty acids also were shown to be present in several commercial fish oil products, and, of potential import to clinicians, the oral administration of small amounts of these fish oils induced tumor resistance to cisplatin in a mouse tumor model.
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In postmenopausal women, constipation is associated with having major risk factors for cardiovascular disease and increased cardiovascular risk.
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This is the second in a three-part series about the design and conduct of clinical research.
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When I was a medicine resident 40 years ago just as the first ICUs were being introduced, treatment for life-threatening bacterial infections consisted of antibiotics, control or removal of the primary source, intravenous fluids, and vasopressors.
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This paper presents the findings from a systematic review and meta-analysis of available randomized, controlled trials (RCTs) published through July 2011 and retrieved from a variety of electronic search databases worldwide.
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Sickle cell disease celebrated its 100th anniversary last year, prompting consideration of what has transpired for those with the disease since its description by Dr. James Herrick in 1910.
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