Cardiology
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Early, goal-directed therapy of septic shock
One thousand two hundred sixty patients with early septic shock were randomized to early, goal-directed therapy vs. usual care. Hemodynamic management according to a strict protocol did not lead to an improvement in outcome.
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Hospital wards with higher rates of antibiotic prescribing associated with increased risk for C. diff infection
A retrospective observational study found that among hospitalized patients, ward-level antibiotic prescribing was associated with a significantly increased risk for C. difficile infection beyond what would be expected with patient-level antibiotic use.
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Vasospastic angina with myocardial infarction – more dangerous than once thought?
Patients with vasospastic angina and a type II myocardial infarction have a worse prognosis than previous believed.
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Do I need atypical coverage for all non-ICU hospitalized patients with community-acquired pneumonia?
Is the accepted treatment for CAP enough, or could we do more?
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Clinical Briefs
Updates on treatment of depression, the prevention and treatment of osteoporosis, and subclinical thyroid dysfunction as it relates to fracture risk.
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Pharmacology Update: Memantine HCl and Donepezil HCl Capsules (Namzaric™)
The addition of memantine to a stable dose of an acetylcholinesterase inhibitor may improve cognitive performance.
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PCSK9: A Major New Advance in Cholesterol-lowering Therapy
When added to statin therapy at the maximum tolerated dose, the PCSK9 inhibitor alirocumab reduced low-density lipoprotein cholesterol levels by 62% and also reduced the rate of occurrence of cardiovascular events.
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Obesity Paradox and Diabetes
In a prospective cohort study of overweight or obese type 2 diabetics, being overweight was associated with a lower mortality risk, but being obese was not.
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Can CPAP Treatment Prevent Dementia?
ABSTRACT & COMMENTARY: Older people with sleep apnea had onset of cognitive decline at an earlier age than those without sleep apnea.
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ECG Review: Is There Complete AV Block or Any Block at All?
We summarize the five parameters to assess in the interpretation of any cardiac rhythm by the saying, “Watch your Ps and Qs — and the 3Rs.”