Cardiology
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Insulin Degludec Injection (Tresiba)
Insulin degludec provides an alternative to insulin glargine and insulin detemir as long-acting human insulin analogs.
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Beta-blocker Dose More Important Than Heart Rate in Systolic Heart Failure
In chronic heart failure with reduced ejection fraction, titrating beta-blocker doses may confer a greater benefit than reducing heart rate.
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Using Procalcitonin to Differentiate Bacterial from Viral Meningitis
A meta-analysis based on nine studies found an elevated serum procalcitonin to be an accurate test for differentiating bacterial from viral meningitis in adults.
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Risk of New Onset Diabetes When Blood Pressure Becomes Elevated Over the Usual Measurement
An increase of 20 mmHg in systolic blood pressure was associated with a 58% higher risk of new-onset diabetes mellitus, whereas an increase of 10 mmHg in diastolic blood pressure was associated with a 52% higher risk of developing new-onset diabetes mellitus.
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Beta-blocker Dose More Important Than Heart Rate in Systolic Heart Failure
Beta-blockers reduce both morbidity and mortality in chronic heart failure with reduced ejection fraction.
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Acetaminophen for Fever in the ICU
SYNOPSIS: Seven hundred ICU patients with fever and known or suspected infection were randomly assigned to receive acetaminophen 1 g IV or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial therapy, or death. Early administration of acetaminophen did not affect number of ICU-free days.
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Clostridium difficile Infection — Back to the Future
SYNOPSIS: This study provides strong evidence that the diagnosis of Clostridium difficile infection (as opposed to colonization) should be made on the basis of evidence of toxin production, not the mere presence of the organism as detected by glutamate dehydrogenase testing or the presence of toxin genes.
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Efficacy and Safety of Very Early Mobilization After Onset of Acute Stroke
SYNOPSIS: The higher dose, very early (within 24 hours) mobilization protocol was associated with a reduction in the odds of a favorable outcome at 3 months after stroke occurrence. -
To Cut Or Not To Cut
ABSTRACT & COMMENTARY: Here are the benefits and the downsides of doing an early cholecystectomy.
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No More Bacon? Carcinogenicity of Meat
A review of published research by the World Health Organization concludes that processed meats are probably carcinogenic.