Cardiology
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Ventricular Tachycardia Ablation vs. Escalation of Antiarrhythmic Drugs in Ischemic Cardiomyopathy
Among patients with an ischemic cardiomyopathy and an implantable cardioverter defibrillator (ICD), catheter ablation was more effective than escalated antiarrhythmic drug therapy in reducing the rate of death at any time or ventricular tachycardia storm or ICD shocks after a 30-day blanking period.
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The Double-edged Sword of Public Mortality Reporting
Since the exclusion of cardiogenic shock from public mortality reporting in New York in 2006, rates of intervention in these patients have risen dramatically. However, these rates remain below those in non-reporting states, suggesting continued reluctance to treat the highest-risk patients due to public reporting.
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Is There HOPE for Blood Pressure Targets in Primary Prevention?
A large randomized trial of fixed-dose antihypertensive treatment in patients at intermediate risk of cardiovascular events with systolic blood pressure < 160 mmHg showed no difference in outcomes vs. placebo.
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Should We SPRINT to Lower Blood Pressure Targets?
ABSTRACT & COMMENTARY: Here's insight into an intensive treatment that resulted in 33% fewer major adverse cardiovascular events.
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Clinical Briefs
In this section: debunking an asthma treatment; more questions than answers with perioperative statin treatment; and another reason to stay away from cocaine.
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Lixisenatide Injection (Adlyxin)
Lixisenatide is indicated as an adjunct to diet and exercise to improve glycemic control in adults suffering from type 2 diabetes mellitus.
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Dual Antiplatelet Therapy Appears More Effective Than Single Therapy
It appears short-term dual antiplatelet therapy is superior to prolonged treatment, but a difference in outcome must be confirmed by further well-designed randomized, clinical trials.
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Greater Weight Loss Later in Life Associated with Increased Risk of Mild Cognitive Impairment
In a population-based, prospective study of subjects ≥ 70 years of age, increasing weight loss per decade from midlife to late-life was associated with an increased risk of incident mild cognitive impairment.
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Wheat Causes Intestinal Immune Activation in Some Patients Without Celiac Disease
Some patients without celiac disease may exhibit wheat sensitivity with demonstrated intestinal epithelial cell damage.
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Too Little of a Good Thing Can Be a Bad Thing
A healthy lifestyle may substantially reduce the burden of cancer.