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Bezlotoxumab Injection (Zinplava)

The FDA has approved a selective, fully human monoclonal antibody directed at Clostridium difficilie toxin B. Binding of toxin B neutralizes its toxic effect. Bezlotoxumab is marketed as Zinplava.

Fecal Transplant vs. Oral Vancomycin Taper for Recurrent Clostridium difficile Infection

In a small randomized, controlled trial that compared fecal microbiota transplant (FMT) administered by enema to a six-week oral vancomycin taper, FMT was not more effective for patients with recurrent Clostridium difficile infection.

Clinical Briefs

In this section: dietary supplement trends, new tools for glucose monitoring, and placebo for osteoarthritis pain.

Crisaborole Ointment (Eucrisa)

Crisaborole is indicated for topical treatment of mild to moderate atopic dermatitis in patients ≥ 2 years of age.

Diabetes and Vitamin C Deficiency May Be Common

In a recent analysis, low levels of vitamin C were noted in seven of 11 patients with diabetes, including six of seven with lower extremity ulcers.

Cardiorespiratory Fitness May Stave Off the Development of Depression

Lower cardiorespiratory fitness increases the risk of developing depression in adults.

Dental Care May Reduce Risk of Pneumonia

While the presence of dental insurance was strongly associated with the frequency of dental check-ups, dental insurance did not appear to affect the risk of pneumonia in the final statistical model.

Pulmonary Embolism Common Cause for Syncope in Hospitalized Patients

It appears pulmonary embolism may be one of the most common causes, and should be considered by all physicians who are evaluating such patients, including neurologists.