Cardiology
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Considering More Intensive Blood Pressure Control in the Elderly
In elderly, hypertensive patients, intensive blood pressure (BP) control (systolic BP < 140 mmHg) decreased major adverse cardiovascular events, including cardiovascular mortality and heart failure.
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Beetroot Juice and Aerobic Endurance and Blood Pressure
Researchers found that drinking beetroot juice daily improves submaximal aerobic endurance in patients with cardiac failure and preserved ejection fraction.
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Low Back Pain: Evidence for Nonpharmacologic Therapies
Developed for use in the new American College of Physicians guidelines, the authors reviewed evidence regarding non-pharmacologic interventions in treatment of low back pain.
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Insomnia Disorder: Evidence for Psychological and Behavioral Interventions
Cognitive behavioral therapy for insomnia (CBT-I) is an effective intervention for moderate to severe insomnia disorder and should be considered as an initial treatment.
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Tai Chi for Knee Osteoarthritis
Tai chi is as effective as a standard course of physical therapy in the treatment of pain of osteoarthritis of the knee.
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Study Challenges Orthodoxy of IV Hydration for Prevention of Contrast Nephropathy
SYNOPSIS: This trial randomized 660 patients with chronic kidney disease and a planned procedure requiring intravascular iodinated contrast to prophylactic hydration or to no hydration. No hydration was found to be non-inferior for prevention of contrast-induced nephropathy and saved significant costs.
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Clindamycin Improves Outcomes in Necrotizing Fasciitis due to Group A Streptococcus
SYNOPSIS: Using a murine model of necrotizing fasciitis, investigators determined that clindamycin inhibits key virulence factors of Group A Streptococcus, and should be given as soon as possible and at high doses to reach levels above MIC in affected tissues.
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Surviving Sepsis Campaign Guidelines Bundle: Studying How Improved Compliance Might Affect Outcomes
SYNOPSIS: Improved compliance with the Surviving Sepsis Campaign guidelines bundle was associated with a non-statistically significant decrease in the in-hospital mortality of severe sepsis patients.
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The ABCs of In-hospital Cardiac Arrest
SYNOPSIS: In this large, propensity-matched cohort study of patients who experienced an in-hospital cardiac arrest, patients who underwent endotracheal intubation had worse survival to hospital discharge than patients who were not intubated.
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Tolvaptan Fails to Improve Dyspnea in Acute Heart Failure
In patients hospitalized for acute heart failure, adding tolvaptan to furosemide lead to increased weight and fluid loss, but did not improve dyspnea at 24 hours.