Cardiology
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Functional Imaging Studies in Parkinson’s Disease
A meta-analysis of 142 studies demonstrated that functional imaging studies in Parkinson’s disease using tracers for aromatic acid decarboxylase showed smaller defects compared to those using tracers targeting dopamine transport and VMAT2. Symptom severity correlated linearly with dopamine neuron loss as determined by these imaging studies.
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A Closer Look at the Effects of NSAIDs on Blood Pressure
An ambulatory blood pressure monitoring substudy of the PRECISION trial showed that ibuprofen use significantly increased mean 24-hour systolic blood pressure compared to celecoxib. Further, naproxen produced intermediate results despite equivalent pain relief in patients with arthritis.
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Kratom Alert: FDA Concerns
Kratom, a plant that is banned in some countries, is available in the United States and has some safety concerns, mostly related to its opioid-like effects.
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Pre-existing Health Determines Quality of Life, Physical Symptoms After ICU Discharge
The authors of this nested cohort study within a randomized, controlled trial of ICU survivors requiring > 48 hours of mechanical ventilation found that pre-existing comorbidity was the main determinant of long-term health-related quality of life.
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Massive Transfusion Protocols: Recommendations Regarding Initiation and Termination
This was a narrative review of societal recommendations for initiation of massive transfusion protocols based on objective scoring systems and clinical assessment and criteria for termination of protocols.
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Implementing Restrictive Transfusion Strategies to Improve Patient Outcomes
There is extensive evidence supporting a restrictive transfusion approach in critically ill patients and cardiac surgery patients. The data favor restrictive strategies in hip and knee surgery, except in geriatric patients for whom evidence favors a more liberal transfusion strategy. Evidence is sparse in sepsis, oncology, and acute coronary syndrome patients, warranting further study.
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Anything Other Than RBBB?
The ECG in the figure was obtained from a 60-year-old woman who presented to the ED with new-onset chest pain. The initial emergency care provider interpreted this tracing as showing complete right bundle branch block. Do you agree?
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Clinical Briefs
In this section: treating COPD with statins, tackling hearing loss with greater urgency, and educating patients about malignant melanomas. -
Insulin Lispro Injection (Admelog)
Admelog is indicated to improve glycemic control in adults and pediatric patients ≥ 3 years of age with type 1 diabetes mellitus and adults with type 2 diabetes mellitus.
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Clostridium difficile Recurrence by Orally Administered Fecal Microbiota Transplantation
Fecal microbiota transplantation orally administered in capsules was non-inferior to administration by colonoscopy.