Cardiology
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Absorb Stent Disappoints Again in 5-Year Data
In this long-term follow up of the ABSORB IV trial, the five-year rate of target lesion failure was significantly higher with the everolimus-eluting bioabsorbable scaffold compared with its metallic counterpart, despite strict adherence to recommended implantation techniques.
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The Safety of Catheter Ablation for Atrial Fibrillation
A meta-analysis of randomized, controlled studies of first catheter ablation for atrial fibrillation showed complication rates are low and have declined over time. Mortality rates are very low and have remain unchanged over the same period.
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Using Artificial Intelligence to Optimize Aortic Stenosis Echocardiographic Surveillance
A machine learning model to predict the frequency of echocardiographic exams in patients with mild-to-moderate aortic stenosis necessary to accurately detect the onset of severe stenosis performed with a high degree of accuracy would reduce the number of unnecessary echocardiograms specified by current guidelines.
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Quality Improvement Project Aims to Decelerate Aggressive Hypertension Treatment
Although there might be good intentions behind administering intravenous antihypertensive medication, staff should remain mindful of possible consequences.
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Direct Oral Anticoagulants vs. Warfarin When Treating Renal Dysfunction
A patient-level meta-analysis of five pivotal trials of direct oral anticoagulants (DOACs) vs. warfarin for patients with atrial fibrillation and creatinine clearance levels ranging from normal to 25 mL/min revealed standard-dose DOACs exhibit superior safety and efficacy compared to adjusted-dose warfarin and lower-dose DOACs.
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The Best Use of Statins in Patients with Coronary Artery Disease
A randomized, multicenter study of high-intensity statin therapy to a treat-to-target approach in coronary artery disease patients showed no difference in three-year outcomes. These results suggest treating to a target may be more suitable to individual patients compared to blanket high-intensity statin use.
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Momentum Continues for Transcatheter Edge-to-Edge Repair
A flurry of recently released study data provided more evidence supporting the efficacy of the minimally invasive heart procedure.
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A Hidden Rhythm
The only clinical information available for this tracing is that the ECG was obtained from an older woman. Without any other background, where should we go from here?
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Sitting, Standing, and Walking: The Effect on Cardiometabolic Markers
The authors of this meta-analysis explored the effects of interrupting sitting with either light-intensity walking or standing. They found light-intensity walking was associated with the most significant effect on several markers of cardiometabolic health.
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Cardiovascular Outcomes with Bempedoic Acid, a New Statin Alternative
A trial of bempedoic acid vs. placebo for statin-intolerant patients showed bempedoic acid significantly lowered LDL cholesterol levels and prevented more major adverse cardiovascular events after a median follow-up of 41 months. Although nonserious side effects were numerically higher for those on bempedoic acid, serious adverse events were not significantly different from placebo.