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Cardiovascular Nutrition Demystified

The authors of this review of key nutritional studies compiled evidence-based information on foods and dietary patterns that support cardiovascular health and demystified those that have incorrectly been identified as beneficial to cardiovascular health.

Medical Cannabis and Chronic Pain

The authors of this systematic review investigating the effects of medical cannabis (MC) on chronic pain in adults found that there is limited evidence to support the use of MC in treating neuropathic pain and that there is insufficient evidence that MC improves other types of chronic pain.

Mediterranean Diet and Frailty Risk

The authors of a review and meta-analysis involving four studies and more than 5,000 community-dwelling adults over the age of 60 years concluded that greater adherence to the Mediterranean diet was associated with a reduced risk of frailty.

Permanent His-bundle Pacing Cardiac Resynchronization: The Way Nature Intended

When used as either a primary alternative to biventricular pacing or a rescue therapy for failed biventricular pacing, permanent His-bundle pacing was associated with significant QRS narrowing, an increase in left ventricular ejection fraction, and an improvement in New York Heart Association functional class.

Age-stratified NT-proBNP Thresholds Identify Acute Heart Failure

In patients presenting to the ED with acute dyspnea, age-based NT-proBNP cutpoints help diagnose acute heart failure.

Are Beta-blockers Indicated for Heart Failure at all LVEF Levels?

A meta-analysis of 11 trials of beta-blockers for heart failure showed that beta-blockers increased left ventricular ejection fraction and reduced cardiovascular mortality in patients in sinus rhythm with baseline ejection fractions < 50%, including those in the 40-49% range.

CABG vs. PCI in Diabetes With Multivessel Coronary Artery Disease and LV Dysfunction

A propensity score-matching analysis of all patients undergoing coronary angiography in Alberta, Canada, identified a subgroup with diabetes, multivessel coronary artery disease, and left ventricular ejection fraction < 50% who were undergoing revascularization and could be separated into a group undergoing percutaneous coronary intervention (PCI) and another coronary artery bypass grafting (CABG). At five years' follow-up, the CABG group experienced significantly fewer major cardiac or cerebral vascular events compared to PCI and a low risk of stroke that was similar to that observed with PCI.

TAVR in Lower-risk Patients: How Low Should We Go?

A meta-analysis of studies comparing transcatheter aortic valve replacement (TAVR) to surgical aortic valve replacement over a two-year follow-up in low surgical risk patients exhibits a higher mortality in the TAVR group, prompting the authors to recommend caution in applying TAVR to low-risk patients until randomized trials are completed.