Cardiology
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MitraClip Falls Short in First Randomized Trial Specific to Functional Mitral Regurgitation
The authors of a recent study concluded that percutaneous mitral valve repair with MitraClip did not significantly alter rates of death and heart failure hospitalization at one year over medical therapy alone.
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Who Really Needs Intensive Blood Pressure Control?
A patient baseline characteristics level analysis of the SPRINT and ACCORD trials resulted in the creation of a simple algorithm for identifying high-risk patients who experienced fewer major cardiac events without increased serious adverse events from intensive blood pressure therapy.
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Elagolix (Orilissa)
Elagolix is indicated for the management of moderate to severe pain associated with endometriosis.
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Treatment of Chronic Subdural Hematoma With Atorvastatin
The results of a recent study suggest that atorvastatin may be a safe and effective nonsurgical alternative for patients with chronic subdural hematoma.
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Inappropriate Outpatient Antibiotic Prescribing: The Need to Target Urgent Care Centers
Urgent care centers, which are part of a growth industry, are responsible for a large proportion of antibiotic prescriptions, including inappropriate prescriptions for acute respiratory diagnoses.
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Latent Tuberculosis Treatment With 4 Months of Rifampin Compared to 9 Months of Isoniazid
In an open-label trial, adults with latent tuberculosis infection were randomized to either four months of treatment with rifampin or nine months of treatment with isoniazid. The four-month rifampin regimen was non-inferior to nine months of isoniazid for prevention of active tuberculosis.
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Vitamin C for Postoperative Atrial Fibrillation Risk
Vitamin C supplementation decreases the risk of developing postoperative atrial fibrillation.
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Use of Amyloid PET Imaging for Diagnosis of Dementia
The use of amyloid PET scanning to assist in accurate diagnosis of patients with symptoms of cognitive impairment as well as frank dementia results in a change of diagnosis in at least 25% of patients.
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Metabolic Acidosis in the ICU
Sodium bicarbonate therapy for severe metabolic acidemia did not affect a primary composite outcome of all-cause mortality at 28 days and at least one organ failure at day 7. However, in an a priori-defined stratum of patients with acute kidney injury, sodium bicarbonate therapy decreased 28-day mortality and the primary outcome.
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Severe Sepsis and Septic Shock Early Management Bundle
When the Severe Sepsis and Septic Shock Early Management Bundle was used to identify patients with severe sepsis or patients in septic shock, delays in lactate measurements for patients with abnormal lactate levels were associated with delayed initiation of antibiotic therapy and increased mortality.