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Shared pathophysiologic mechanisms for migraine, neuropathic pain, and epilepsy underscore the notion that antiepileptic drugs (AED) should be standard treatment for the former. Five new AEDs and their use in these nonepileptic painful disorders are summarized.
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Increased iron stores (eg, ferritin levels) are associated with an increased risk of type 2 diabetes in women.
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The first of a class of calcimimetics has been approved by the FDA for the treatment of hyperparathyroidism associated with renal failure and in patients with parathyroid cancer.
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These data provide further support that inflammation in general and periodontal disease more specifically are stroke risk factors.
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High-dose atorvastatin protects patients with acute coronary syndrome from death and major cardiovascular events better than usual dose pravastatin.
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Although beta-blockers are known to reduce the sensitivity of exercise and dobutamine sestamibi SPECT imaging for the detection of coronary artery disease, little is known about their effects on vasodilator stress scintigraphy. Thus, Taillefer and colleagues studied 21 patients with catheter proven coronary artery disease during 3 different treatments on different days assigned in a random fashion.
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A United Kingdom survey of sudden arrhythmic death syndrome in 32 victims aged 4-64 with normal hearts at autopsy and a negative toxicologic screening test evaluated first-degree relatives of these victims.
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In this paper, Oral and colleagues compared 2 current ablation techniques in patients with paroxysmal atrial fibrillation.
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This widely publicized small trial has catapulted the mutant form of ApoA-1 Milano into the limelight. Many investigators have been working with this interesting lipoprotein since it was discovered in the 1980s that 38 carriers from a small village in Northern Italy have very low HDL levels but very little vascular disease.
