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Trauma surgeons at the Regional Medical Center at Memphis carried out a randomized clinical trial comparing a continuous ethanol infusion with a protocol of scheduled diazepam administration for the prevention and control of severe alcohol withdrawal syndrome (AWS) among patients admitted to their ICU following trauma.
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This multicenter, randomized, double-blind, placebo-controlled trial of hydrocortisone replacement in septic shock aimed to evaluate 28-day mortality in non-responders to corticotropin stimulation.
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Stop smoking drug Chantix rates stronger warning from FDA; Type 2 diabetes surgery on the way?; Vytorin study inconclusive; Influenza A virus found resistant to Tamiflu; FDA actions.
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In this study, goldenberg and colleagues from the MADIT-II study analyzed risk factors for mortality in that trial. MADIT-II was a randomized trial of ICD versus conventional therapy, which included 1232 patients with documented previous myocardial infarctions who had an ejection fraction of ≤ 30%.
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It remains debatable as to whether individuals who present with a non-ST-segment elevation MI (NSTEMI) or acute coronary syndrome (ACS) should be managed with a selective or elective invasive strategy vs an approach performing angiography in all patients.
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Anticoagulation with vitamin k antagonists is the standard recommendation for patients with nonvalvular atrial fibrillation and risk factors for stroke. The benefits of warfarin in such patients have been well shown in many clinical trials. Therapy with warfarin, however, is often complicated by the dietary and drug interactions, so that even with frequent monitoring, precise control of the anticoagulation level is difficult.
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The differentiation of constrictive pericarditis from restrictive cardiomyopathy can be difficult, but the treatment implications are great.
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Patients with a positive CT scan for coronary calcium often have a stress test. Askew and colleagues from the Mayo Clinic asked whether such patients should undergo repeat stress testing if the first one is negative or low risk?