Cardiology
RSSArticles
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Combination Drug Therapy for Hypertension
A large regional database study from Italy revealed that initial combination therapy for newly diagnosed hypertension results in fewer major adverse cardiovascular events at one year compared to monotherapy.
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Clinical Outcomes After Oral Anticoagulant-Associated Intracerebral Hematoma
In this meta-analysis of multiple observational studies, clinical outcomes after oral anticoagulant-associated intracerebral hematoma were similar for those associated with vitamin K antagonists or the new class of direct oral anticoagulants.
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Apolipoprotein E and CSF Levels in Men and Women With Alzheimer’s Disease
Apolipoprotein E epsilon 4 (APOE4) genotype, the stronger genetic risk factor for late-onset Alzheimer’s disease, negatively affects cerebrospinal levels of tau protein in a sex-dependent manner, whereby the effect of APOE4 is stronger in women than men.
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Revefenacin Oral Inhalation (Yupelri)
Revefenacin should be used to help patients with COPD.
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Antipsychotics Do Not Shorten the Duration of ICU Delirium
In this randomized, placebo-controlled trial, neither haloperidol nor ziprasidone altered the duration of delirium when compared to placebo.
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PCSK9 Inhibitors in Acute Coronary Syndrome Patients
Compared to adding placebo, using the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab in post-acute coronary syndrome patients on maximally tolerated, high-intensity statins with low-density lipoprotein (LDL) cholesterol levels higher than 70 mg/dL lowered LDL and reduced the number of major adverse cardiac events.
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Caregivers and Mindfulness-Based Stress Reduction Interventions
A Cochrane Review regarding efficacy of mindfulness-based stress reduction (MBSR) for family caregivers of dementia patients revealed low-quality evidence that MBSR reduces short-term anxiety and depressive symptoms in this population.
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Hormone Therapy and Mortality: No Overall Effect?
An evaluation of outcomes of users and nonusers of postmenopausal hormonal therapy followed longitudinally in the Danish database showed no overall difference in mortality.
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Cinnamon for Dysmenorrhea: A Clinical Trial
Cinnamon, three grams daily, for the first few days of menstruation may help attenuate menstrual pain in women suffering from dysmenorrhea, although an improved follow-up clinical trial is necessary to corroborate this.
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Can Quality of Diet Lower the Risk of Depressive Symptoms?
In a meta-analysis of 42 studies, researchers found that subjects who reported following the Mediterranean diet closely had a 0.67 reduced risk of developing depressive symptoms compared with low adherence to this diet.