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In this issue: New reports about proton pump inhibitors and the effects of gastric suppression, pioglitazone vs vitamin E for non-alcoholic steatohepatitis, metformin and vitamin B12 deficiency, and FDA Actions.
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Patients with neuromuscular disease who are intubated and subsequently fail multiple spontaneous breathing trials are often relegated to placement of a tracheo-stomy and continuous mechanical ventilation.
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Terragni et al performed this 4-year-long multicenter randomized controlled trial to determine whether early (6-8 days) vs late (13-15 days) tracheotomy would reduce ventilator-associated pneumonia (VAP) incidence.
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A well-established body of epidemiologic literature supports a continuous graded risk between systolic blood pressure (SBP) and CV risk. This relationship has held constant whether one considers office BP, home BP, or ambulatory blood pressure monitoring (ABPM).
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The FDA has approved a miconazole buccal tablet for the treatment of oropharyngeal candidiasis. This once-daily mucoadhesive buccal tablet provides slow release of the drug over the course of the day. The tablet is marketed by Strativa Pharmaceuticals as Oravig™.
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Contrary to the current guidelines, in the long term, an average of approximately 60 min/day of moderate-intensity activity for women is required to be successful in maintaining a normal weight.
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Being overweight or obese increases the risk of cirrhosis. In this study, excess body weight contributed to almost 20% of the cirrhosis-related hospital admissions and deaths, while alcohol contributed to almost 50%.
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The presence of cerebral complications of infective endocarditis (IE) can affect diagnostic and treatment decisions. Thus, this group from Paris, France, evaluated whether early cerebral MRI would affect the diagnosis and management of hospitalized patients suspected of having IE.
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Carotid-artery stenting (CAS) has evolved significantly over recent years to become a reasonable alternative to carotid endarterectomy (CEA) for selected patients with carotid-artery disease.