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Mitochondrial oxidative stress and damage is connected to neuronal cell death and behavioral outcomes after TBI. Antioxidant treatment with the amide form of N-acetylcsyteine, which has central nervous system (CNS) bioavailability, was shown to improve markers of damage and cognitive function in rats when provided by intraperitoneal injection post experimental TBI.
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This randomized, parallel group study over 12 months found greater weight and cardiovascular risk benefits in obese adults eating a low-carbohydrate diet vs a low-fat diet.
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A polysaccharide-rich extract of turmeric rhizome provided benefits in people with knee osteoarthritis.
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This study completes the Imazio et al trilogy on the treatment of pericarditis and suggests that colchicine is the drug of first choice for acute pericarditis, first recurrences, and multiple recurrences.
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This observational cohort study found that reduced ICU bed availability is associated with increased rates of ICU readmission as well as ward cardiac arrest if medical ICU beds were on shortage.
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In this retrospective study of extubation outcomes in five ICUs at a single medical center, patients extubated at night had no increase in adverse events and their mortality rates and lengths of ICU stay were lower. However, these results were likely affected by the high proportion of post-cardiac-surgery patients in the nighttime extubation group.
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The authors present an updated review of the use of tissue plasminogen activator in patients with acute ischemic stroke.
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This is an eight-week, cluster-randomized, controlled trial at a single institution study (Stanford Hospital) comparing a traditional one-way paging system to the use of a HIPAA-compliant group messaging (HCGM) application for smartphones.
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