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Chromosome banding analysis (CBA) of marrow metaphase cells is the standard method to assess response in CML. The authors compared CBA to interphase fluorescence in situ hybridization (I-FISH) in 664 samples where both methods were performed.
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In a retrospective review of 71 patients treated in either a second- or third-line setting for small-cell lung cancer (SCLC) at a single institution, three orally administered drugs (lomustine, etoposide, and cyclophosphamide) were shown to be effective in producing responses (overall response rate 38%) but had little effect on overall survival (median survival 19 weeks).
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Results from a Phase 3 study of dabigatran, intensive lipid-lowering in CVD, H1N1 vaccine dosing and efficacy, and FDA Actions
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A 68-year-old white female presented to her internist complaining of fatigue for the past month. The patient is a piano teacher who traveled to her students' houses for their lessons, which had become a significant effort for her.
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In this review of 195 patients with metastatic breast cancer, detection of 5 or more circulating cancer cells in 7.5 mL of whole blood correlated with reduced overall survival. Furthermore, the presence of extensive bone metastases, as detected by PET/CT, was shown to be associated with increased circulating tumor cells (CTC).
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Among funeral workers, the duration of embalming practice and related formaldehyde exposure were significantly associated with an increased risk for mortality from myeloid leukemia.
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Data continue to be generated related to the use of robotic surgery in gynecology. At the current time, what the future holds for this latest technology within our specialty is anyone's guess.
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The authors analyzed data from the Women's Health Initiative (WHI) combined Estrogen/Progestin Trial to determine if new-onset breast tenderness (NOBT) was associated with the development of breast cancer.
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In the last two months, there were four articles in the American Journal of Obstetrics & Gynecology and Obstetrics & Gynecology dealing with drugs that are commonly used in pregnancy and their possible contribution to adverse outcomes. One of these articles was particularly attention-getting.