Although users of depot medroxyprogesterone acetate (DMPA) experienced more bone fractures than users of other contraceptives, their risk of bone fractures was higher at baseline before initiating DMPA and did not change while on DMPA. This suggests that confounding, unknown factors led to the association between DMPA and fractures in previous studies.
In a large, multicenter, randomized study of women in Europe who presented with ectopic pregnancy, there was no significant difference in the rate of subsequent intrauterine pregnancy observed following early ectopic pregnancy managed with medical therapy or conservative (salpingostomy) surgery, or following acute ectopic pregnancy managed with radical (salpingectomy) or conservative surgery.
Tubal sterilization is a highly effective, permanent, and safe method of contraception. Tubal sterilization is the second most common method of contraception used by women in the United States and the most common among women over 30 years of age.
In this issue: Calcium supplementation in women; type 2 diabetes treatments and pancreatitis risk; treating chronic idiopathic urticaria; rivaroxaban and VTE; and FDA actions.
Although the levonorgestrel intrauterine system (LNG IUS) has been shown to be an effective treatment for heavy menstrual bleeding (HMB), previous clinical trials included rigorous criteria focused primarily on measuring the severity of bleeding.
During the past few months, there has been a pleth-ora of articles published with important clinical implications, and I have found it difficult to pick just one to review.
LAP2 was a phase 3 clinical trial to assess the non-inferiority of laparoscopy compared with laparotomy for recurrence of uterine cancer after surgical staging.
This Phase 1 clinical trial evaluated the safety and pharmacokinetics of intraventricular immune-chemotherapy with twice weekly rituximab (10 mg and 25 mg) and methotrexate in 14 patients with recurrent central nervous system lymphoma (primary or secondary).
