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Calcium supplementation in women; type 2 diabetes treatments and pancreatitis risk; treating chronic idiopathic urticaria; rivaroxaban and VTE; and FDA actions.
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In this Phase 2 trial, 105 older patients with acute myeloid leukemia who were either treatment-naïve or at first relapse were treated with one of three schedules of oral sapacitabine: 200 mg twice daily for 7 days (group A), 300 mg twice daily for 7 days (group B), or 400 mg twice daily for 3 days each week for 2 weeks (group C).
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Denosumab is more effective than zoledronic acid at preventing pain in women with advanced breast cancer and bone metastases.
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In a six-site Italian retrospective analysis, treatment of elderly patients with metastatic renal cell carcinoma with sunitinib was shown to be effective but associated with significant toxicity. Although only applied to a subset, pretreatment comprehensive geriatric assessment did not offer predictive value with regard to severe toxicity or efficacy.
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Early pivotal trials demonstrating the efficacy of sorafenib for patients with advanced hepatocellular cancer included primarily those with minimal liver dysfunction (Child-Pugh [CP] class A).
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LAP2 was a randomized, Phase 3 trial to evaluate and compare the modality of surgical staging (laparoscopy vs laparotomy) in endometrial cancer.
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In a prospective cohort of obese, reproductive-aged women, there were no changes in the number of ovulatory cycles, but there was a shortening of the follicular phase and an improvement in sexual function after gastric bypass surgery.
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OB/GYN Clinical Alert editorial board transitions.
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Overt maternal hypothyroidism and hyperthyroidism each complicate about 3/1000 pregnancies. However, subclinical hypothyroidism can accompany as many as 2.5% of pregnancies. Both problems require careful surveillance because of the potential to cause significant maternal and fetal complications.
