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LAP2 was a randomized, Phase 3 trial to evaluate and compare the modality of surgical staging (laparoscopy vs laparotomy) in endometrial cancer.
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Early pivotal trials demonstrating the efficacy of sorafenib for patients with advanced hepatocellular cancer included primarily those with minimal liver dysfunction (Child-Pugh [CP] class A).
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In a six-site Italian retrospective analysis, treatment of elderly patients with metastatic renal cell carcinoma with sunitinib was shown to be effective but associated with significant toxicity. Although only applied to a subset, pretreatment comprehensive geriatric assessment did not offer predictive value with regard to severe toxicity or efficacy.
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Denosumab is more effective than zoledronic acid at preventing pain in women with advanced breast cancer and bone metastases.
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In this Phase 2 trial, 105 older patients with acute myeloid leukemia who were either treatment-naïve or at first relapse were treated with one of three schedules of oral sapacitabine: 200 mg twice daily for 7 days (group A), 300 mg twice daily for 7 days (group B), or 400 mg twice daily for 3 days each week for 2 weeks (group C).
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Calcium supplementation in women; type 2 diabetes treatments and pancreatitis risk; treating chronic idiopathic urticaria; rivaroxaban and VTE; and FDA actions.
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In a large, multicenter, randomized study of women in Europe who presented with ectopic pregnancy, there was no significant difference in the rate of subsequent intrauterine pregnancy observed following early ectopic pregnancy managed with medical therapy or conservative (salpingostomy) surgery, or following acute ectopic pregnancy managed with radical (salpingectomy) or conservative surgery.
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Although users of depot medroxyprogesterone acetate (DMPA) experienced more bone fractures than users of other contraceptives, their risk of bone fractures was higher at baseline before initiating DMPA and did not change while on DMPA. This suggests that confounding, unknown factors led to the association between DMPA and fractures in previous studies.