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By examining a large series of patients who had PET/CT scans obtained within 2 months of diagnosis of metastatic breast cancer, it was discovered that site-specific SUV correlated with survival. This was most apparent and statistically significant when comparing survival for patients with bone metastases, although similar but not statistically significant data also were presented for patients with liver, lung, or lymph node involvement.
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This retrospective cohort study of 12,500 women with breast cancer, treated in the community, compared the incidence of congestive heart failure in those who received trastuzumab-containing adjuvant chemotherapy regimens with those who did not. There was a four-fold increase in the risk of heart failure in women who received trastuzumab alone and a seven-fold increase in those who received anthracycline plus trastuzumab.
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Uterine (papillary) serous cancer is a genomically unstable cancer associated with poor survival even in stage i. it is also frequently associated with a secondary malignancy, particularly breast cancer. Comprehensive surgical staging is recommended since extrauterine disease can be present without other high-risk uterine features, like myometrial invasion. However, an optimal adjuvant treatment protocol remains to be defined.
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Menopausal hormone therapy and risk of VTE and AD; patients' understanding of chemotherapy benefits; and FDA actions.
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In an analysis of a well-characterized dataset capturing outcomes for patients with asymptomatic, low-burden follicular lymphoma, those managed by initial watchful waiting had outcomes similar to comparable patients who were treated at the time of diagnosis with regimens including rituximab. Thus, delayed initial therapy remains a reasonable approach for selected follicular lymphoma patients.
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A 61-year-old nuclear engineer with a past history of hypertension was admitted through the emergency department because of persistent lower abdominal pain. Clinical picture and imaging studies initially pointed to pelvic abscess.
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In this issue: Dementia and benzodiazepines; effectiveness of omega-3 fatty acid and Ginkgo biloba supplements; and FDA actions.
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Although the incidence of hysterectomy has declined in recent years, it remains the most common major gynecologic procedure, and many women are offered or consider elective bilateral oophorectomy (BSO) at the time of hysterectomy to reduce ovarian cancer risk.
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Mediators of the autonomic response to stress, such as the catecholamines norepinephrine and epinephrine, promote cancer growth, metastasis, and progression in preclinical models.
