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Side effects of finasteride; new ruling on pharmaceutical companies paying generic manufacturers; and FDA actions.
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A multi-institutional study examined the addition of a purine analog, either cladribine or fludarabine, to the standard induction regimen ("7 & 3") in adult patients 60 years of age and younger with acute myelogenous leukemia, and found improved outcomes for those receiving cladribine. The added benefit from cladribine appears to be the result of a reduction in the incidence of resistant disease. The study arm containing cladribine, daunorubicin, and cytaribine yielded an overall survival at 3 years of 45% while conventional "7 & 3" therapy was only 33% at 3 years. Cladribine added to daunorubicin and cytarabine during remission induction improves leukemia control and patient survival for those 60 years of age and younger.
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In this Phase 2 trial, 11 patients with relapsed/refractory primary central nervous system lymphoma after high-dose, methotrexate-based regimen were treated with pemetrexed 900 mg/m2 every 3 weeks, dexamethasone 4 mg bid, folate, and B12 supplementation. The treatment had an overall response rate of 55%, disease control rate of 91%, median progression free survival of 5.7 months, and median overall survival of 10.1 months. Toxicities were more than expected with the standard pemetrexed dose (500 mg/m2) and were primarily hematologic and infectious, which were easily managed. Although single-agent activity of pemetrexed in this study is novel and promising, optimal dosing and efficacy need to be studied further.
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Is azithromycin proarrhythmic? Macrolide antibiotics are associated with an increased risk of sudden cardiac death, but azithromycin (Zithromax), the popular "Z pack" macrolide, has been considered safe.
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The authors sought to estimate trends in prenatal drug exposure and neonatal abstinence syndrome (NAS) in Washington State from 2000 to 2008.
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You've seen her before. she's often young and partnered, but might be midlife and changing the status of her relationship. Sometimes she presents for an annual exam and mentions her pain later during the visit. Occasionally she actually presents with the complaint of dyspareunia.
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Gestational diabetes (gdm) now complicates about one in 15 pregnancies, but, undoubtedly, the prevalence will increase even further if we cannot curb the concerning rise in obesity in this country.
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The authors assessed the risk of venous thrombosis (vt) in current users of non-oral hormonal contraception using four national registries in Denmark.
