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It has been shown that delayed cord clamping after delivery will increase the blood volume of term and preterm neonates without any apparent downside complications, except for an inability to administer resuscitation to those who need it immediately.
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Outcome data from 52,218 u.s. participants in the international Active Surveillance of Women Taking Oral Contraceptives (INAS) study were used to analyze contraceptive failure in association with typical use of oral contraceptive (OC) pills.
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After two pretreatment cycles, 196 patients with menorrhagia were randomized to tranexamic acid or placebo.
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In this issue: Apixaban and rivaroxaban near approval for nonvalvular atrial fibrillation; fidaxomicin for C. difficile infections; guideline for intensive insulin therapy; and FDA Actions.
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HPV infection is a major cause of morbidity in both genders. HPV vaccination (both bivalent and quadrivalent) has proved effective in girls and women, including those outside of the original age indications and those with prior sexual activity. Much less is known of vaccine efficacy in boys and men for the prevention of HPV-associated diseases.
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Escitalopram for menopausal hot flashes, rifaximin for IBS without constipation, herpes zoster vaccination, antiepileptics drugs and fracture risk, and FDA Actions.
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Myelodysplastic syndromes (MDS) usually occur in older adults and, as such, comorbid conditions are common. The investigators found that among 418 MDS patients, at least one comorbid condition existed in 93% at diagnosis. Comorbidity scores were generated using three common scoring systems: the HCT-CI, MDS-CI, and CCI. Worse survival was linked to higher CCI (p = 0.01) and MDS-CI (p = 0.02) but not HCT-CI. Higher CCI scores were associated with non-leukemic death and progression of red blood cell dependency, whereas higher comorbidity by HCT-CI and MDS-CI did not. Higher comorbid burden by CCI in MDS predicts for worse survival and non-leukemic death. Comorbidity data may help refine prognosis for MDS patients.
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Uric acid as a weak organic acid (pka 5.8) is poorly soluble at physiological pH.
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A 84-year-old retired professor was referred for second opinion regarding management of prostate cancer. He had been relatively healthy, with a history of hyperlipidemia and gout.
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