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Isoflurane causes mitochondrial disruption and apoptosis in neuronal and hippocampal cells, and decreases memory consolidation in mice. Such effects are not seen with desflurane. This may impact selection of anesthetic agents for patients with Alzheimer's disease undergoing surgical procedures.
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The clinicopathological features of nine patients with pure autonomic neuropathy, with or without antiganglionic acetylcholine antibody, were assessed. There was considerable variability in the clinical manifestations, course, unmyelinated nerve fiber loss, and response to therapy.
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Children with isolated growth hormone deficiency have lower IQ, worse motor skills, and several brain regions with smaller volumes than carefully selected controls.
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Of all ischemic stroke patients treated with iv al- teplase (tPA), only about half will achieve recanalization and have a good outcome (mRS 0 to 2).
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Needle EMG is safe in patients who are taking therapeutic doses of antiplatelet or anticoagulant medications.
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This study validated that anti-aquaporin-4 antibodies are highly specific (99.8%) for Devic's disease and related disorders when tested in a large series of miscellaneous autoimmune and non-autoimmune systemic diseases.
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Small fiber neuropathy (SFN) is a relatively common disorder that affects small somatic and/or autonomic nerves. Known causes include diabetes, vitamin B12 deficiency, and Sjogren's syndrome among others, although the condition is idiopathic in most cases.
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Detailed neuropathological investigation of patients with sensory neuronopathy and polymerase γ mutations revealed evidence of posterior column atrophy in spinal cord sections and marked neuronal cell loss with severe mitochondrial biochemical abnormalities (involving respiratory chain complexes I and IV) in the dorsal root ganglia.
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New treatment for prostate cancer; avastin and breast cancer; new CMS disclosure rule; and FDA actions.
