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Early seizures and EEG abnormalities as well as status epilepticus predicts worse outcome in SCN1A-positve Dravet syndrome in this new, large cohort of patients.
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Two recently reported Phase 3 trials for BG-12 demonstrated efficacy and safety in the treatment of relapsing-remitting multiple sclerosis.
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A Simple Score Can Predict Outcome after Ischemic Stroke; Mismatch Between Perfusion and Diffusion on MRI Can Identify Good Candidates for Endovascular Reperfusion Therapy; Cerebral Microbleeds May Be Associated with Elevated Vascular Endothelial Growth Factor
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Behçet's disease, while rare in North America, should be considered when appropriate, in light of the extensive travel and immigration patterns around the world.
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Thrombolysis for Ischemic Stroke Associated with Cervical Artery Dissection Does Not Improve Overall Outcome; In Patients with Lacunar Strokes, Addition of Clopidogrel to Aspirin Does Not Reduce Risk of Recurrent Stroke; Risk of Restenosis After Carotid Artery Stenting and Carotid Endarterectomy Are Similar
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Intravenous erythropoietin therapy appears to reduce retina nerve fiber layer thinning 16 weeks after onset of optic neuritis, but larger studies needed to detect differences in visual outcome.
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Biomarkers in the cerebrospinal fluid open the possibility of diagnosing early or even presymptomatic cases of Alzheimer's disease, thereby expanding the potential window for therapy.
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This case series of patients with painful legs and moving toes is the largest to date and describes association with female gender, peripheral neuropathy and radiculopathy, cancer, and autoimmune disorders. Neurophysiology suggests an additional central component, supporting recruitment of a spinal cord or brainstem generator.
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Side effects of statins; effects of cannabis use; antihypertensives and lip cancer; and FDA actions.
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